| 血清cystatin C对小儿肾功能受损诊断的评价 |
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| 引用本文： | 陈莎,王佳,邱艳,刘芳,艾洪武. 血清cystatin C对小儿肾功能受损诊断的评价[J]. 临床儿科杂志, 2011, 29(4). DOI: 10.3969/j.issn.1000-3606.2011.04.012 |
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| 作者姓名： | 陈莎 王佳 邱艳 刘芳 艾洪武 |
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| 作者单位： | 武汉市妇女儿童医疗保健中心检验部,湖北武汉,430016 |
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| 摘 要： | 目的 探讨儿童肾小球肾炎患者血清cystatin C(Cys C)水平与肾功能损害程度之间关系.方法 血清Cys C采用乳微粒子增强比浊法测定,血尿素氮(BUN)采用动力学紫外法测定,血肌酐(sCr)采用酶法测定,内生肌酐清除率(Ccr)采用肌氨氧化酶PAP法计算.结果 肾小球肾炎患者肾功能正常期Cys C明显高于正常对照组(P ＜ 0.01),BUN、sCr与对照组差异无统计学意义(P均＞ 0.05);肾功能不全代偿期,Cys C、sCr与正常对照组差异有统计学意义(P均＜ 0.01),而BUN与正常对照组差异无统计学意义(P ＞ 0.05);肾功能不全失代偿期及肾衰竭期,Cys C、BUN、sCr值与正常对照组差异有统计学意义(P均＜ 0.01).肾小球肾炎各期Cys C与BUN、sCr、Ccr均呈正相关(P ＜ 0.01).结论 血清Cys C可敏感地反映肾小球滤过功能受损程度,可作为早期诊断肾小球肾炎的血清学指标.
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| 关 键 词： | 肾功能 肾小球肾炎 |
Serum cystatin C in evaluation of the diagnosis in children with impaired renal function |
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| CHEN Sha,WANG Jia,QIU Yan,LIU Fang,AI Hong-wu. Serum cystatin C in evaluation of the diagnosis in children with impaired renal function[J]. The Journal of Clinical Pediatrics, 2011, 29(4). DOI: 10.3969/j.issn.1000-3606.2011.04.012 |
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| Authors: | CHEN Sha WANG Jia QIU Yan LIU Fang AI Hong-wu |
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| Affiliation: | CHEN Sha,WANG Jia,QIU Yan,LIU Fang,AI Hong-wu(Department of Laboratory Medicine,Wuhan Medicial and Health Center For Women and Children,Wuhan 430016,Hubei,China) |
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| Abstract: | Objective To study the relationship of serum cystatin C(Cys C)level with renal function in pediatric patients with glomerulonephritis.Methods Serum Cys C level was determined by a particle-enhanced turbidimetric immunoassay.Blood urea nitrogen(BUN)was measured by UV-kinetic assay.Serum creatinine(sCr)was measured by enzymatic assay.Endogenous creatinine clearance rate(Ccr)was calculated by muscle oxidase Peroxidase-Antiperoxidase method.Results In glomerulnephritis patients with normal renal function,the le... |
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| Keywords: | cystain C |
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