| 二硫化碳对雌性小鼠的性腺毒作用 |
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| 引用本文： | 张文昌 江一平. 二硫化碳对雌性小鼠的性腺毒作用[J]. 毒理学杂志, 1992, 6(1): 24-25 |
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| 作者姓名： | 张文昌 江一平 |
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| 作者单位： | 福建医学院劳动卫生学教研室，福建医学院组织胚胎学教研室 福州 350004 |
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| 摘 要： | 进行了雌性小鼠CS_2染毒后卵巢连续切片的组织学观察和超数排卵(人工诱发排卵)试验。<1>卵巢组织学观察结果:原始卵泡数在各实验组间无显著性差异;初级卵泡和次级卵泡数CS_2高剂量组均显著低于CS_2低剂量组和对照组(P<0.05);闭锁卵泡呈明显增多趋势;<2>超数排卵试验结果:GS_2染毒组与对照组间平均超排卵数无显著性差异(P>0.05)。提示CS_2性腺毒作用可以表现为卵泡生长发育成熟的明显障碍,而卵巢对于超量促性腺激素作用的反应机能基本正常。
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| 关 键 词： | 二硫化碳 性腺 毒性 超数排卵 |
The Gonad Toxicity of Carbon Disulfide in Femal Mice |
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| Zhang Wen Chang,et al.. The Gonad Toxicity of Carbon Disulfide in Femal Mice[J]. Journal of Toxicology, 1992, 6(1): 24-25 |
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| Authors: | Zhang Wen Chang et al. |
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| Abstract: | Experimental studies on the effect CS2 on the ovary inICR mice was conducted.Histolo-gical observation of consective sections of ovary showod that the difference in the number of primodial follicle both primary and secondary was not significant ( P>0.05 ) , however it was sigificantly lower in CS1-group than that in control ( P<0.05 ) and the atresia folliclli also increased;Superovulation assays showed that the average of eggs ovulatcd in CS2-gr-oup was not different from that in control ( P>0.05 ) .It was suggeted that the toxic effect of CS2 on the ovary can be showed as the inhibition of follieled evelopment. The reactivity of ovary to gonadotropic hormone ( higher level ) was normal. |
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| Keywords: | Carbon disulfide Gonad toxicity Histological observation Superovulation assay. |
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