Two new 18-carbon norditerpenoid alkaloids from Aconitum sinomontanum |
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| Authors: | Tan J-J Tan C-H Ruan B-Q Jiang S-H Zhu D-Y |
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| Affiliation: | a State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, Chinab Fujian Institute for Drug Control, Fuzhou, China |
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| Abstract: | Two new 18-carbon norditerpenoid alkaloids, sinaconitines A (1) and B (2), together with two known alkaloids, ranaconitine (3) and lappaconitine (4), were isolated from the roots of Aconitum sinomontanum. Their structures were elucidated on the basis of spectral evidences and X-ray crystallographic analysis for 1. Furthermore, the reversed 13C NMR assignments for C-10 and C-13 of 3, 4, puberanine, puberanidine and demethyllappaconitine were revised. Compounds 1-4 were evaluated for cyclooxygenase-2 (COX-2) enzyme inhibitory activity. However, they did not show any inhibition at 10 μM. |
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| Keywords: | Sinaconitine A Sinaconitine B Norditerpenoid alkaloid Aconitum sinomontanum |
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