Research of Active Immunotherapy on Unexplained Recurrent Spontaneous Abortion（URSA）

There are many factors which may cause URSA except for chromosome abnormality, dyscrinism, infection, autoimmunologic disease, uterine malformation and etc. And 40%- 70% of them can not be identified and we called unexplained recurrent spontaneous abortio…

Research of Active Immunotherapy on Unexplained Recurrent Spontaneous Abortion(URSA)

Objective To investigate the effect of active immunotherapy on unexplained recurrent sponta- neous abortion(URSA)during the process of gestation and delivery period. Methods We collected the data of the women with URSA and their offsprings. The women were treated by immunization with paternal lymphocytes and then had a successful pregnancy. The fore mentioned group of women were compared with those who had a normal pregnancy and then delivered in the same period. Results The incidences of premature rupture of membranes, adherent placenta, and residual cauls in the group of URSA patients were statistically higher than those in the normal group. Correspondingly, gestational age at delivery and birth weight of the newborns of the group of URSA patients were lower, but there were no significant differences between the two groups . Conclusion These results indicate that paternal lymphocyte immunotherapy is effective on the maintenance of pregnancy in women with URSA, and has no deleterious effects on the fetus or newborns. However, in case of the higher incidence of premature rupture of membranes, adher- ent placenta, and residual cauls, more attention should be paid to the treated patients to avoid intrauterine growth retardation and postpartum hemorrhage.