| 阿魏酸钠对大白鼠实验性心肌缺血再灌注损伤的保护作用 |
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| 引用本文： | 张卫国,张志善,喻学刚,杨德章.阿魏酸钠对大白鼠实验性心肌缺血再灌注损伤的保护作用[J].武汉大学学报(医学版),1992(3). |
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| 作者姓名： | 张卫国 张志善 喻学刚 杨德章 |
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| 作者单位： | 湖北工学院药理教研室，湖北工学院药理教研室，湖北医学院病生教研室，湖北工学院药理教研室 |
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| 摘 要： | 阿魏酸钠800mg/kg 灌胃15d,然后进行结扎大白鼠左枝冠状动物45min.解除结扎恢复血流灌注60min,复制大自鼠心肌缺血再灌注损伤模型。观察该药对心肌缺血再灌注损伤的影响。结果:阿魏酸钠明显提高心肌组织超氧化物歧化酶活性,降低心肌丙二醛含量和减少心肌细胞的肌酸磷酸激酶释放,(Creatine phosphokinase,CPK),减轻再灌注导致心肌超微结构损伤。提示,阿魏酸钠对大白鼠心肌缺血再灌注损伤有保护作用。作用机理与抗氧化作用有关。
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| 关 键 词： | 心肌/超微结构 心肌/药物作用 阿魏/药物学 灌注法 |
Protective Effect of Natrii Ferulatis on Myocardial Ischemia Reperfusion Injury in Rats |
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| Zhang Weiguo Zhang Zhishan Yu Xuegang.Protective Effect of Natrii Ferulatis on Myocardial Ischemia Reperfusion Injury in Rats[J].Medical Journal of Wuhan University,1992(3). |
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| Authors: | Zhang Weiguo Zhang Zhishan Yu Xuegang |
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| Institution: | Zhang Weiguo~1 Zhang Zhishan~1 Yu Xuegang |
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| Abstract: | 800 mg/kg·d of Natrii Ferulatis(NF)was given orally to rats for 15 days.The myocardial is- chemia reperfusion injury modal was produced bythe occlusion of the left coronary artery and the re- lease of the occlusion in rats,significanntly improving myocardial SOD activity,reducing MDA con- tent and cardial CPK release,also portecting myocardial ultrastructure,keeping them from the oxygen free radical damage.These results indicate that NF have a protective effect on myocardial ischemia/ reperfusion injury probably by inhibiting the oxygen free radicals and subsequence lipid peroxidation. |
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| Keywords: | myocardium/UL myocardium/PE freula/PD perfusion |
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