血清肿瘤标志物检测诊断卵巢肿瘤的临床价值

目的 探讨检测肿瘤标志物在妇科肿瘤中的临床应用价值。方法采集卵巢恶性肿瘤24例、卵巢囊肿57例及29例健康成年女性外周血3ml，分离血清，检测血清AFP、CEA、CAS0、CA125和CA199的含量，分析这五项肿瘤标志物单独与联合检测在卵巢肿瘤诊断的应用价值。结果卵巢囊肿组AFP、CEA、CAS0和CA199的含量平均值均在正常参考值范围内，CA125的平均值高于正常参考值；与对照组比较，AFP、CA125和CA199的含量差别有统计学意义（P〈0．01）。恶性肿瘤组CA50、CA125和CA199含量平均值高于正常参考值（P〈0．01）；CEA含量差异与对照组和良性组比较均无统计学意义（P〉0．05）。卵巢囊肿组肿瘤标志物单独检测的阳性率除CA125达到26．32％以外，其余4种的阳性率均较低，联合检测阳性率为33，33％；恶性肿瘤组除CEA单独检测阳性率较低为12．50％外，其余单独检测时阳性率都超过50％（P〈0．01），联合检测时阳性率为91．67％（P〈0．01）。结论AFP、CA50、CA125和CA199联合检测在卵巢恶性肿瘤诊断有较高的临床价值。

The clinical applied value of detection of tumor markers in the diagnosis of ovarian tumor

Objective To evaluate the diagnostic value of detecting the serum tumor-marker in patients with gynecologic tumors pre-operation. Methods The serum levels of AFP,CEA,CA50,CA125,and CA199 in 24 patients with ovary cancer,57 patients with benign ovary tumor and 29 normal women were examined by using radioimmunoassay. Results The average levels of AFP,CEA,CA50 and CA199 of patients with benign ovary tumor were normal and that of CA125 was beyond the normal value.The average level of serum AFP,CA125 and CA199 in benign or malignant and normal ones were significantly different as compared with that of the normal controls(P<0.01);comparing with the normal and benign group,the average level of CEA in malignant patients showed no significant diference(P>0.05). The positive rate of CA125 in benign ones was 26.32%,the positive rate of other four markers detected by combination test was 33.33%;level of CEA individually detected in malignant ones was 12.5%,the positive rates of others markers wre all above 50%(P<0.01),the positive rate of of markers detected by combination test was 91.67%(P<0.01). Conclusion The combined detection of AFP,CA50,CA125 and CA199 possesses relatively high value in clinical diagnosis of malignant ovary tumor preoperation.