Inhibitory effect of zinc oxide on contact allergy due to colophony |
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Authors: | Thor A.,Sö derberg ,Theoder,Elmros ,Rolf,Gref Gö ran,Hallmans |
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Affiliation: | Department of Hand Surgery, University Hospital of Ume?, Sweden. |
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Abstract: | Contact allergy to a wound dressing with an adhesive mass consisting of colophony, zinc oxide and rubber (Mezinc) was studied in 179 patients with a history of eczema. 12 patients were found to be allergic to colophony, whereas only 4 of these patients also showed a positive patch test reaction to the wound dressing. 14 patients with verified moderate contact allergy to colophony were patch tested with adhesive mass (10%), Portuguese colophony (10%), zinc oxide (10%), purified resin acids (10%), and Portuguese colophony (10%), in combination with zinc oxide. Only 3 patients reacted to the adhesive mass, whereas all patients showed a positive patch test reaction to Portuguese colophony. A combination of zinc oxide (10%) with Portuguese colophony (10%) provoked a positive patch test reaction in only 5 of these 14 patients. An allergic reaction to abietic acid (90-95% purity) was found in 7 patients and to neoabietic acid (99 + %) in 3 patients, whereas no reactions to dehydroabietic (99 + %), isopimaric (99 + %) or levopimaric acids (98 + %) were found. |
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Keywords: | colophony adhesive tape allergic contact dermatitis abietic acid dehydroabietic acid neoabietic acid isopimaric acid levopimaric acid zinc oxide |
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