| 新型两亲性壳聚糖衍生物的合成、表征及对黄芩苷的增溶作用 |
| |
| 引用本文： | 张爱丰,余祥正. 新型两亲性壳聚糖衍生物的合成、表征及对黄芩苷的增溶作用[J]. 临床医学工程, 2011, 18(5) |
| |
| 作者姓名： | 张爱丰 余祥正 |
| |
| 作者单位： | 张爱丰 (暨南大学药学院,广东,广州,510632) ； 余祥正 (暨南大学药学院,广东,广州,510632) ； |
| |
| 基金项目： | 暨南大学科研培育与创新基金青年基金 |
| |
| 摘 要： | 目的合成一种新型两亲性壳聚糖衍生物并考察其对黄芩苷的增溶作用。方法壳聚糖与十二烷基硫酸钠反应生成SCS,对SCS进行羧甲基化后,得到两亲性壳聚糖衍生物(CMSC)。用红外光谱和核磁共振氢谱表征了衍生物的结构,并探讨了CMSC溶液对黄芩苷的增溶作用。结果黄芩苷在CMSC溶液中于8~12h达溶解平衡,且溶解度随着CMSC浓度的增加而增大。当CMSC的浓度为2mg/mL时,黄芩苷的溶解度达到1.5046mg/mL,是其在水中溶解度的5.88倍。结论 CMSC在水溶液中可自组装形成胶束,并对黄芩苷有明显的增溶作用,有潜在的应用价值。
|
| 关 键 词： | 两亲性 壳聚糖 黄芩苷 十二烷基硫酸钠 |
Synthesis and Characterization of Novel Amphiphilic Chitosan Derivative and Its Solubilizing Abilities for Baicalin |
| |
| Abstract: | Objective To prepare and characterize a novel amphiphilic chitosan derivative and investigate the solubilization abilities of CMSC for baicalin.Methods An amphiphilic chitosan derivative(CMSC) with long alky groups and carboxymethyl groups was synthesized.The chemical structure of CMSC was characterized by FTIR and 1H NMR.The solubilization abilities of CMSC for baicalin were evaluated.Results The balance time of baicalin dissolved in CMSC was 8 ~ 12 h and the solubility increased with the increasing concentration of CMSC.The maximum was 1.5046 mg/mL which was about 5.88 times as much as that in water.Conclusion CMSC can increase the solubility of baicalin obviously,which can be potentially useful as an insoluble drug carrier. |
| |
| Keywords: | Amphiphilic Chitosan Baicalin SDS |
|
|
