| EB病毒和ConA诱导抑制性T细胞对EB病毒感染B细胞作用探讨 |
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| 引用本文： | 黄添友 赵明伦. EB病毒和ConA诱导抑制性T细胞对EB病毒感染B细胞作用探讨[J]. 中国病理生理杂志, 1993, 9(2): 227-230 |
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| 作者姓名： | 黄添友 赵明伦 |
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| 作者单位： | 第一军医大学中西医结合研究所，广东湛江医学院病理生理学教研室，广东湛江医学院病理生理学教研室 广州 510515 |
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| 基金项目： | 广东省高等院校自然科学基金 |
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| 摘 要： | 本文探讨了用灭活的EB病毒(EBV)和ConA诱导产生的抑制性T细胞(Ts),对EBV感染自身B细胞的影响,结果表明,EBV抗原诱导产生的抑制性T细胞(Ts)能使EBV感染B细胞中的EBNA阳性细胞数,~3H-TdR掺入量和IgA、IgG及IgM分泌量减少;而ConA诱导产生的Ts则使EBNA阳性细胞数和~3H-TdR掺入量增加,但三种Ig含量无明显变化(P>0.05)。结果提示前者对EBV感染B细胞的激活,增殖和分化均有明显抑制作用,而后者的作用则相反,具有明显促进EBV感染B细胞的作用。
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| 关 键 词： | 病毒 淋巴细胞 鼻咽肿瘤 免疫抑制 |
Effect of the Epstein-Barr Virus(EBV) and Con A induced suppressor T cells on the EBV infected B lymphocytes in vitro |
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| Huang Tian-You,Zhao Ming-Lun,et al Institute of Traditional Chinese Medicine and Western Medicine of PLA,Guangzhou. Effect of the Epstein-Barr Virus(EBV) and Con A induced suppressor T cells on the EBV infected B lymphocytes in vitro[J]. Chinese Journal of Pathophysiology, 1993, 9(2): 227-230 |
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| Authors: | Huang Tian-You Zhao Ming-Lun et al Institute of Traditional Chinese Medicine Western Medicine of PLA Guangzhou |
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| Abstract: | The effect of the inactivated EBV and Con A induced suppressor T cellson the EBV infected B lymphocytes was investigated in this study. The results showedthat EBV induced suppressor T cells (EBV-Ts) could decrease the number of EBV nuclearantigen (EBNA) positive cells, cpm of the ~3H-TdR incorporation and the level of secre-ting Ig in the EBV iofected B lymphocytes, while Con A induced Ts (Con A-Ts) couldincrease them. This indicated that the effects of the EBV-Ts and Con A-Ts on the EBVinfected B cells were completly different. One could inhibit while the other enhance theactivation, proliferation and differention of the EBy infected B lymphocytes in vitro. |
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| Keywords: | Mitogens Suppressor T cells Epstein-Barr virus B lymphocytes |
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