| 糖尿病红细胞膜钠泵K^＋pNPPase活性与红细胞变形能力的关系 |
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| 引用本文： | 王浩然,邱鸿鑫.糖尿病红细胞膜钠泵K^＋pNPPase活性与红细胞变形能力的关系[J].中国病理生理杂志,1993,9(6):715-717. |
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| 作者姓名： | 王浩然 邱鸿鑫 |
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| 作者单位： | 四川省人民医院内科内分泌组，重庆医科大学附一院内科，重庆医科大学附一院内科 成都 610072 |
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| 摘 要： | 本文测定５０例ＮＩＤＤＭ患者红细胞膜钠泵Ｋ＾＋－ｐＮＰＰａｓｅ活性和红细胞滤过指数ＩＦ。结果显示：ＮＩＤＤＭ患者红细胞膜钠泵Ｋ＾＋－ｐＮＰＰａｓｅ活性降低和红细胞ＩＦ明显增高，上述改变在ＮＩＤＤＭ伴有视网膜病变者更为显著；红细胞膜钠泵Ｋ＾＋－ｐＮＰＰａｓｅ活性降低和红细胞ＩＦ呈负相关。提示红细胞膜钠泵Ｋ＾＋－ｐＮＰＰａｓｅ活性降低可能是导致红细胞变形能力降低的重要因素。
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| 关 键 词： | 糖尿病 非胰岛素 依赖型 红细胞膜 |
Erythrocyte membrane Na-pumping K~+-pNPPase activity and red cell deformability in diabetes mellitus |
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| Wang Hau-Zan,Qiu Hong-Xin,et al.Erythrocyte membrane Na-pumping K~+-pNPPase activity and red cell deformability in diabetes mellitus[J].Chinese Journal of Pathophysiology,1993,9(6):715-717. |
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| Authors: | Wang Hau-Zan Qiu Hong-Xin |
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| Institution: | Wang Hau-Zan,Qiu Hong-Xin,et al Department of Endocrinology,Si Chuan Provinal People's Hospital,Chengdu |
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| Abstract: | The activity of erythrocyte membrane Na-pumping K~+-activated pera-nitro-phenylphosphatase (K~+-pNPPase) and red cell deformability (RCD) were stndied in 50adult patients with non-insulin-dependent diabetes mellitus (NIDDM). RCD was expressedas red blood cell filtration index (RBC-IF). In comparison with the healthy subject, theactivity of erythrocyte membrane Na-pumping K~+-pNPPase was significantly decreased,and RBC-IF was significantly increased. The above-mentioned changes were more severein NIDDM with retinopathy than those without. There was a very close negative corre-lation between Na-pumping K~+-pNPPase and RBC-IF. These results indicated that thedecrease of erythrocyte membrane Na-pumping K~+-pNPPase activity might be an importantfactor fot the decrease of RCD. |
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| Keywords: | Diabetes mellitus Non-insulin-dependent Erythrocyte membrane |
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