| 碱性成纤维细胞生长因子对小鼠口腔唇部创伤的促愈合作用 |
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| 引用本文： | 杜克难. 碱性成纤维细胞生长因子对小鼠口腔唇部创伤的促愈合作用[J]. 中国病理生理杂志, 1993, 9(2): 244-247 |
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| 作者姓名： | 杜克难 |
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| 作者单位： | 暨南大学医学院组胚教研室 广州 |
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| 摘 要： | 本研究用外科手术方法切除小鼠口腔唇部皮肤及粘膜,造成局部创伤,使用以基因工程方法生产的碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)涂擦创面。经病理组织学检查,创面完全愈合时间为4--5天,对照组、肝素组及碱性成纤维细胞生长因子加肝素联合使用组时间为9--10天。本文提示,碱性成纤维细胞生长因子有促进口腔唇部软组织创伤愈合的作用,肝素对碱性成纤维细胞生长因子的生物学活性有明显的抑制作用。
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| 关 键 词： | 口腔 唇 生长因子 细胞 创伤 |
The effect of bFGF on wound healing of mice lips |
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| Du Ke-Nan. The effect of bFGF on wound healing of mice lips[J]. Chinese Journal of Pathophysiology, 1993, 9(2): 244-247 |
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| Authors: | Du Ke-Nan |
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| Affiliation: | Du Ke-Nan Department of Histology and Embryology,Medical College of Jinan University,Guangzhou |
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| Abstract: | The skin and tunica mucosa of mice lips were cut off by surgical opera-tion. To the local wound of mice lips was applied the basic fibroblast growth factorwhich was produced by gene engineering method. The time to achieve a complete healingtook 4-5 days. The time for control group, bFGF heparin group and heparin grouptook 9-10 days. These resuits suggested that bFGF had an accelerat healing effect to thelip tissue of mice. Obviously heparin can inhibit the biological activity of basic fibro-blast growth factor. |
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| Keywords: | Growth subslances Mouth Lip |
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