宣威肺癌遗传因素作用大小的估算与分析

目的 探讨肺癌的遗传方式,估算肺癌肺癌发病过程中遗传因素作用的大小,以期进一步完善宣威肺癌的病因学研究。方法 利用遗传流行病学的理论与方法,选择了370例肺癌先证者,同时以每位肺癌先证者的配偶为对照且形成对照组。结果 肺癌的分离比为0．15,肺癌的遗传度为24．6％,其中男性为14．6％,女性为37．8％。结论 遗传因素与肺癌的发病密切相关,是肺癌的重要危险因素。肺癌遗传属多基因遗传。遗传因素在女性产生肺癌的过程中作用较大;但不论是男性还是女性发生肺癌,遗传因素都不是宣威肺癌高发的主要危险因素。

The general measurement of genetic factors on lung cancer in Xuanwei, China

Objective To investigate the hereditary model of lung cancer and to determine measurement of genetic factors on lung cancer. Methods With methods of genetic epidemiology, 370 probands of lung cancer and 370 spouses of the probands (control) were studied. Results The segregation ratio of lung cancer was 0.15 and the genetic model of lung cancer belonged to polygenetics.The heritability of lung cancer was 24.6%, 14.6% for male and 37.8% for female. Conclusion The genetic model of lung cancer is polygenetics.The genetic susceptibility of female with lung cancer is higher than that of male. The genetic factor is one of the risk factors on lung cancer but the environmental factors are still the most important risk factors.