消化内科住院患者抗生素相关性腹泻危险因素分析

目的：探讨分析消化内科住院患者抗生素相关性腹泻（ AAD）危险因素。方法：回顾性分析本院消化内科住院448例应用抗生素患者资料，将发生AAD患者作为AAD组，未发生AAD患者作为对照组，对可能影响患者AAD发生各因素进行单因素分析，对于单因素分析具有统计学差异的各因素进一步采取Logistic回归分析。结果：在448例患者中，发生AAD患者39例，AAD发生率为8．71％；经单因素分析及Logistic回归分析结果显示，抗生素使用种类多、抗生素使用时间长、患者年龄偏大以及住院时间长四个因素进入回归模型（ P＜0．05）。结论：抗生素使用种类多、抗生素使用时间长、患者年龄偏大以及住院时间长是消化内科住院患者AAD发生独立危险因素，只有提高消化内科临床医生对AAD的认识，加强对患者的预防措施，合理运用抗生素，才能有效降低AAD的发生率。

Risk factors of antibiotic associated diarrhea in hospitalized patients in department of digestive medicine

Objective:To investigate the risk factors of antibiotic associated diarrhea( AAD) in hospitalized patients with diges-tive diseases.Methods:A retrospective analysis of the length of use of antibiotics in 448 cases in gastroenterology department of our hospital.The patients with AAD were assigned to the group of AAD, while those without AAD to control group.Factors possibly associated with AAD were analyzed by univariate analysis and logistic regression analysis was applied for the factors with statistical difference.Results:In 448 patients, 39 patients with AAD, and the incidence of AAD was 8.71%.The single factor analysis and logistic regression analysis showed that four factors, combinations of antibiotics, long treatment period with antibiotics, the aged and hospitalization period, were adopted in regression model (P<0.05).Conclusion:The length of treatment period with antibi-otics, the number of the used antibiotics, the senior patients and the length of hospital stay are independent risk factors in patients with AAD.It is important for physicians to understand AAD, strength preventive measures and rational use of antibiotics to reduce the incidence of AAD effectively.