黄花远志根和叶提取物对急性肝损伤小鼠的保护作用

目的：研究黄花远志根和叶提取物对四氯化碳（CCl4）所致急性肝损伤小鼠的保护作用。方法：采用 CCl4诱导化学性急性肝损伤模型，测定小鼠肝脏指数、血清丙氨酸氨基转移酶（ALT）和天门冬氨酸氨基转移酶（AST），观察小鼠肝脏病理学变化。结果：黄花远志根（4 g、2 g 生药／ kg）和叶（4 g、2 g 生药／ kg）提取物能显著降低 CCl4致小鼠急性肝损伤ALT 和 AST 的升高，明显改善 CCl4对肝组织的病理损伤。结论：黄花远志根和叶对 CCl4致小鼠急性肝损伤具有保护作用。

Protective effects of extraction of roots and leaves from polygala arillta on CCl 4 - induced acute hepatic injury in mice

Objective:To study the protective effects of extraction of roots and leaves from Polygala arillta against CCl4 - induced liver injury in mice. Methods:The models of acute liver injury were induced by CCl4 in mice. The liver index,serum activities of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)were determined,respectively. Liver tissue sections were examined under a light microscope. Results:In the model of acute liver injury induced by CCl4 in mice,roots(4 g/ g and 2 g/ kg) and leaves(4 g/ kg and 2 g / kg)from Polygala arillta markedly decreased the elevated serum levels of ALT and AST. The extrac-tion of roots and leaves from Polygala arillta effectively improved the tissue lesion of liver. Conclusion:Polygala arillta has a signifi-cantly hepatoprotective effect on CCl4 - induced acute liver injury in mice.