| 补肾化瘀解毒方药物血清对肺癌A549/DDP耐药细胞内药物浓度的影响 |
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| 引用本文： | 曹勇,张丹,郑广娟,张静. 补肾化瘀解毒方药物血清对肺癌A549/DDP耐药细胞内药物浓度的影响[J]. 山东中医药大学学报, 2003, 27(5): 389-391 |
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| 作者姓名： | 曹勇 张丹 郑广娟 张静 |
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| 作者单位： | 暨南大学医学院,中医系,广东,广州,510632;山东中医药大学,山东,济南,250014 |
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| 基金项目： | 山东省中医管理局资助项目 ( 2 0 0 1 0 7) |
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| 摘 要： | 探讨补肾化瘀解毒方对肺癌耐药细胞内DDP浓度的作用 ,选择人肺腺癌耐药细胞株A5 4 9/DDP为模型 ,采用荷瘤动物血清药理及流式细胞法 ,结果补肾化瘀解毒方荷瘤动物含药血清能显著提高肺癌A5 4 9/DDP耐药细胞内DDP浓度 (P <0 .0 5 ) ,与正常动物含药血清无显著性差异 (P >0 .0 5 ) ,表明补肾化瘀解毒方含药血清能提高肺癌耐药细胞内化疗药物浓度 ,对探讨补肾化瘀解毒方逆转肺癌耐药性具有重要作用。
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| 关 键 词： | 补肾化瘀解毒方 肺癌耐药逆转 血清药理学 细胞内药物浓度 流式细胞法 |
| 文章编号： | 1007-659X(2003)05-0389-03 |
| 修稿时间： | 2003-02-24 |
EFFECTS OF DRUG-SERUM OF BUSHEN HUAYU JIEDU FORMULA ON DDP CONCENTRATION IN LUNG CANCER DRUG-RESISTANCE A549/DDP CELLS |
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| CAO Yong ,ZHANG Dan ,ZHENG Guang juan ,ZHANG Jing. EFFECTS OF DRUG-SERUM OF BUSHEN HUAYU JIEDU FORMULA ON DDP CONCENTRATION IN LUNG CANCER DRUG-RESISTANCE A549/DDP CELLS[J]. Journal of Shandong University of Traditional Chinese Medicine, 2003, 27(5): 389-391 |
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| Authors: | CAO Yong ZHANG Dan ZHENG Guang juan ZHANG Jing |
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| Affiliation: | CAO Yong 1,ZHANG Dan 2,ZHENG Guang juan 2,ZHANG Jing 2 |
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| Abstract: | To explore the effects of Bushen Huayu Jiedu formula on DDP concentration in lung cancer drug resistance A549/DDP cells,pharmacology method with tumor bearing animals drug serum and method with flow cytometry were used. The results showed Bushen Huayu Jiedu formula enhanced DDP concentration(P<0.05, compared with the control group)markedly,which was same as that in normal animal drug serum(P>0.05). All the above indicated Bushen Huayu Jiedu formula can increase chemotherapy drug concentration in lung cancer drug resistance cells,and is an important role to explore in reversing drug resistance effects in lung cancer cells. |
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| Keywords: | Bushen Huayu Jiedu formulae reversion of drug resistancein in lung cancer cell serum pharmocology drug concentration flow cytometry |
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