子宫平滑肌瘤487例临床病理分析

目的:探讨子宫平滑肌瘤的发病年龄,发病部位,组织学分型,合并症,病因.方法:子宫活检,石蜡包埋切片,HE染色,根据WHO子宫平滑肌瘤新分类进行组织学分型.结果:487例子宫活检,病变部位有三种:肌壁间多见,浆膜下,粘膜下少见.发病年龄多在40-50岁.组织学有三种分型:平滑肌瘤479例(97%),平滑肌肉瘤2例(1%),恶性潜能未定5例(2%).合并症有子宫内膜过增生,腺肌瘤或腺肌症,卵巢囊肿,子宫内膜息肉,输卵管积水,畸胎瘤,颗粒细胞瘤,提示子宫平滑肌瘤发生与雌激素水平升高有关.结论:子宫平滑瘤的合并症更进一步证实子宫平滑肌瘤发生与雌激素水平升高有关.

Clinical pathological analysis of uterine leimyomas in 487cases

Objective:To study the age-related incidence,location,histological classification,complication,and pathogenesis of uterine leiomymas.Methods:Histological classification according to WHO new classification method was performed with the uterine biopsy and pathological study.Results:The age-related incidence was 40-50 year old mostly.The masses were seen intra-smooth muscle mostly,but sub-serosa and sub-mucus membrane rarely.There were three classes:leiomyomas in 479 cases(97%),sarcoma in 2 cases(1%),and uncertain potential malignancy in 5 cases(2%).The complication included overproliferation of uterine intima,adenomyoma,ovarian cyst,uterine intima polup,ovarian hydrops,teratoma,and granular cell neoplasm.Conclusions:These complications confirms that the pathogenesis of uterine leiomyomas is associated with the elevation of estrogen level.