脂蛋白、载脂蛋白与原发性高血压的关系

探讨氧化修饰低密度脂蛋白( oxLDL)、脂蛋白(a)Lp(a)]、载脂蛋白A1(ApoA1)及载脂蛋白B100(ApoB100)在原发性高血压(EH)发病、进展中的作用.方法:应用双抗夹心ELISA法和免疫比浊法测定EH患者血液中oxLDL、Lp(a)、ApoA1及ApoB100含量.结果:EH患者血液中oxLDL和ApoB100明显高于正常对照组(P＜ 0.05和P＜0.001),Lp(a)和ApoA1与正常对照组差异以及各项性别、年龄间差异均无显著性(P＞0.05).结论:oxLDL、ApoB100参与EH的病理过程,其升高是EH常伴有动脉粥样硬化的重要机制之一.

Correlation between lipoprotein/apolipoprotein and essential hypertension

Objective:To investigate the relation of lipoprotein and apolipoprotein with the pathogenesis of essential hypertension(EH).Methods:The levels of oxidatively modified low density lipoprotein(oxLDL),lipoprotein(a),apolipoprotein A\-1(ApoA\-1) and apolipoprotein B 100 (ApoB 100 ) in plasma or serum of patients with EH were determined by sandwich ELISA and immunoturbimetric method.Results:The levels of plasma oxLDL and serum ApoB 100 of EH group were obviously higher than those of normal control group( P < 0.05 and P <0.001).The differences of Lp(a) and ApoA\-1 in EH group from those in normal control group were not significant( P >0.05).There were no significant differences of sex and age between EH group and normal control group( P >0.05).Conclusions:OxLDL and ApoB 100 in the blood take part in pathologic course of EH and their decreases may be one of the important mechanisms of EH often accompanied by atherosclerosis(AS).