阿尔茨海默病相关血液学标志物研究进展

阿尔茨海默病(AD)是一种中枢神经系统退行性疾病,主要临床表现为记忆、认知障碍以及后期的人格和行为改变等。有很多血液学指标和AD密切相关,如蛋白质、基因突变、微小RNA(miRNA)等,或可用于预测AD发生风险、反映疾病阶段及支持AD诊断。血液学标志物的检测简便、易行,因此,筛选理想的AD相关血液学标志物有利于AD的筛查与治疗。文章总结了AD相关血液学标志物的研究现状,并讨论其应用于临床的可能性和局限性。

Progressive research of Alzheimer's disease-related blood markers

Alzheimer's disease(AD)is a degenerative disease of the central nervous system with clinical manifestations of memory impairment,cognitive impairment,later personality and behavioral changes.Recently,studies have shown that many blood markers are closely related to AD,like protein,gene mutation,microRNA(miRNA),which may play a certain role in predicting the risk of AD,reflecting the stage of AD and supporting the diagnosis of AD.In addition,the determination method of blood markers is simple and easy,therefore screening ideal AD-related blood markers is beneficial to the screening and treatment of AD.In this review,the latest research status of AD-related blood markers is summarized,and the possibility and limitation of its clinical application are discussed.