鄂州市342例新型冠状病毒肺炎患者实验室检测指标与临床分型相关性分析

目的分析鄂州市新型冠状病毒肺炎(COVID-19)患者实验室检测指标与临床分型的相关性。方法选取2020年1月23日-2月12日鄂州市中心医院COVID-19住院患者342例,其中普通患者196例(普通组)、重症患者97例(重症组)、危重症患者49例(危重症组)。对各组年龄、性别、基础疾病、合并感染情况、血液学指标进行比较。采用受试者工作特征(ROC)曲线评价各项指标对COVID-19的辅助诊断价值。结果 3组之间年龄、基础疾病患病率差异均有统计学意义(P<0.05),危重症组男性比例高于女性(P<0.05);3组之间其他呼吸道病原体合并感染率差异有统计学意义(P<0.05),感染率最高的均为肺炎支原体感染和乙型流感病毒感染。与普通组比较,重症组淋巴细胞百分比(LYMPH%)、总蛋白(TP)、白蛋白(Alb)显著降低(P<0.05),D-二聚体(DD)、纤维蛋白原(Fg)、红细胞沉降率(ESR)、C反应蛋白(CRP)显著升高(P<0.05);与重症组比较,危重症组LYMPH%、TP、Alb显著降低(P<0.05),白细胞(WBC)、DD、降钙素原(PCT)显著升高(P<0.05)。ROC曲线分析结果显示,区分普通患者与重症患者最有价值的指标是ESR、Alb和LYMPH%;区分重症患者与危重症患者最有价值的指标是PCT、LYMPH%、Alb。结论检测COVID-19患者ESR、Alb、LYMPH%和PCT等指标有助于判断病情。

Correlation of laboratory index and clinical classification among 342 corona virus disease 2019 patients in Ezhou

Objctive To investigate the correlation of laboratory index and clinical classification in corona virus disease 2019(COVID-19)patients.Methods A total of 342 patients with COVID-19 in Ezhou Central Hospital from January 23,2020 to February 12,2020 were enrolled.There were 196 cases of general group,97 cases of severe group and 49 cases of critical group.Their age,sex,basic diseases,co-infection and blood indexes were compared.Receiver operating characteristic(ROC)curve was used to evaluate the roles of blood indexes in the diagnosis of COVID-19.Results The age and prevalence of basic diseases among the 3 groups had statistical significance(P<0.05).The proportion of males in critical group was higher than that of females(P<0.05).The infection rate of co-infection with other respiratory pathogens had statistical significance among the 3 groups(P<0.05).The infection rates of Mycoplasma pneumoniae and influenza B virus were the highest.In severe group,lymphocyte percentage(LYMPH%),total protein(TP)and albumin(Alb)were lower than those in general group(P<0.05),while D-dimer(DD),fibrinogen(Fg),erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP)were higher(P<0.05).In critical group,LYMPH%,TP and Alb were lower than those in severe group(P<0.05),while white blood cell(WBC)count,DD and procalcitonin(PCT)were higher(P<0.05).According to ROC curve analysis,ESR,Alb and LYMPH%were the most valuable blood indexes to distinguish general and severe groups,and PCT,LYMPH%and Alb were the most valuable blood indexes to distinguish severe and critical groups.Conclusions ESR,Alb,LYMPH%and PCT determinations are helpful to diagnose the conditions.