NET-1、EGFR在肺癌中的表达及意义 |
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引用本文: | 卞伟钢,胡平,宋曙,何啸,王传斌,陈萍,陈莉. NET-1、EGFR在肺癌中的表达及意义[J]. 首都医药, 2011, 0(4): 30-32 |
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作者姓名: | 卞伟钢 胡平 宋曙 何啸 王传斌 陈萍 陈莉 |
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作者单位: | 1. 江苏省盐城市第一人民医院,224001 2. 南通大学,226001 |
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摘 要: | 目的探讨NET-1、EGFR在肺癌中的表达及临床意义。方法采用免疫组织化学SP法,检测120例肺癌及10例正常肺组织(对照组)中NET-1、EGFR的表达。结果 NET-1、EGFR在肺癌中的阳性表达率(85.00%、69.16%)明显高于癌旁肺组织(40.00%、10.00%)。NET-1、EGFR蛋白在肺癌中的表达差异与患者性别、年龄、病变部位无关(均P>0.05),但与肺癌组织的分化程度、临床分期、有无淋巴结转移相关(P<0.05)。结论 NET-1、EGFR具有促进肿瘤细胞转化、增殖、迁移的作用,可作为临床判定肺癌恶性程度的指标。
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关 键 词: | 肺癌 NET-1 表皮生长因子 |
The expression and significance of NET-1 and EGFR in lung cancer |
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Abstract: | Objective To explore the expressions and significance of NET-1 and EGFR in lung cancer. Methods SP immunohistochemical staining was used to examine the expressions of NET-1and EGFR in 120 human lung cancer specimens and in 10 normal lung tissues. Results The positive rates of NET-1 and EGFR in lung cancer (85.00% and 69.16% respectively) were significantly higher than those in the normal tissue(40.00% and 10.00% respectively).NET-1 and EGFR expressions were not correlated with age,sex and tumor position(P>0... |
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Keywords: | NET-1 |
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