培哚普利并美托洛尔治疗充血性心力衰竭的临床观察

目的:观察培垛普利,美托洛尔联合治疗慢性充血性心力衰竭(CHF)病人对心功能,心率,心胸比及左室射血分数(LVEF)的影响。方法:CHF病人60例随机分为2组,对照组28例采用洋地黄,利尿剂,培垛普利治疗,治疗组32例采用洋地黄,利尿剂,培垛普利,美托洛尔治疗,疗程均6周。结果:治疗组经治疗后,心率减慢,血压降低,心胸比缩小,LVEF提高,与治疗前比较有显著性差异(P<0.05)。而对照组治疗后心率减慢,心胸比缩小,血压降低,LVEF提高,但与治疗前比较无显著性差异。治疗组治疗后心率,血压,心胸比,射血分数与对照组相比有显著性差异(P<0.05)。结论:培垛普利,美托洛尔联合治疗CHF,可明显使病人心率减慢,血压降低,心胸比缩小,LVEF提高。

Clinical investigation of perindopril combined with metoprlol in treating patients with congestive heart failure

Objective: To investigate the influence of perindopril combined with metoprlol on the cardiac function, heart rate, heart chest ratio and left ventricular ejection fraction (LVEF) in patients with congestive heart failure (CHF). Methods: Sixty patients with CHF were divided into two groups. The perindopril and metoprlol treatments were on the basis of conserved therapy in therapeutic group. Control group was treat with conserved therapy and perindopril. Both groups were treated for six weeks. Results: In the therapeutic group, the heart rate slowed, the heart chest ratio, blood pressure decrased and the LVEF increased after treatment (P<0. 05). However in the control group, the above stated parameters were not significant change after treatment. Above stated parameters were significant difference between two groups (P<0. 05). Conclusion: Perindopril combined with metoprlol can decrease heart rate, blood pressure and heart chest ratio, and raise LVEF in patients with CHF.