哌布可罗宁潘可罗宁临床药效的比较研究

应用剂量递增法检测哌布可罗宁，潘呆罗宁的ＥＤ９５值，并观测不同等效剂量ｐｉｐ，ｐａｎ神经－肌阻滞效应及气管插管时肌松条件。结果表明：ｐｉｐ的ＥＤ９５小于ｐａｎ，肌松效能略强于后者，但等效剂量两药的起铲时间，气管插管时的肌松条件，恢复相似于；１．５及２倍ＥＤ９５剂量的ｐｉｐ，ｐａｎ均可获得较满意的气管插管条件，２ＥＤ９５剂量可缩短起效时间及提前进行气管插管，但２ＥＤ９５ｐｉｐ明显延长肌松作用时间及增

Comparative Clinical Pharmacodynamic Study of Pipecuronium Bromide and Pancuronium Bromide

The ED 95 values for pipecuronium bromide(pip) and pancuronium bromide(pan)were determined with incremental dose method,the ncuromuscular blocking action and intubation condiation were observd after administrated different muscle relaxants and doses(2ED 95 pip,2ED 95 pan,1 5ED 95 pip,1 5ED 95 pan).The results show that the ED 95 value for pip was smaller than that for Pan ,the pip is more potent than pan.When equipotent dose of pip and pan was adminstrated the onset time,intubation condition and recovery index of pip were similar to those of pan.2ED 95 pip can shorten the onset time and make intubation earlier but prolong the duration of clinical relaxantion.