| 克矽平对矽肺大鼠Ⅰ、Ⅲ型胶原mRNA水平的影响 |
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| 引用本文： | 缪庆,刘秉慈,何玉先,王海华,尤宝荣. 克矽平对矽肺大鼠Ⅰ、Ⅲ型胶原mRNA水平的影响[J]. 卫生研究, 1995, 0(3) |
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| 作者姓名： | 缪庆 刘秉慈 何玉先 王海华 尤宝荣 |
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| 作者单位： | 中国预防医学科学院劳动卫生与职业病研究所 |
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| 摘 要： | 克矽平（Ｐｏｌｙｖｉｎｙｌｐｙｒｉｄｉｎｅ－Ｎ－ｏｘｉｄｅ，ＰＶＮＯ）是一种较为有效的抗矽肺药物。作者采用编码人Ⅰ、Ⅲ型胶原α１（Ⅰ）及α１（Ⅲ）链的ｃＤＮＡ探针，使用ｃＤＮＡ－ｍＲＮＡ斑点杂交技术，观察了染尘２个月、４个月及经克矽平治疗１、３个月的矽肺大鼠肺组织中Ⅰ、Ⅲ型胶原ｍＲＮＡ水平的改变情况。实验结果表明：大鼠染尘后２、４个月，肺组织中Ⅰ、Ⅲ型胶原ｍＲＮＡ水平较正常鼠肺组织有明显上升（Ｐ＜０．０５），经克矽平治疗后，Ⅰ、Ⅲ型胶原的ｍＲＮＡ水平显著下降。提示：克矽平对矽肺进程中胶原基因表达的增强有抑制作用。
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| 关 键 词： | 矽肺，克矽平，mRNA，胶原 |
Type Ⅰ and type Ⅲ collagen mRNA levels in silicosis of rats treated by polyvinylpyridine-N-Oxide |
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| Miao Qing,Liu Bingci,He Yuxian,Wang Haihua,et al.. Type Ⅰ and type Ⅲ collagen mRNA levels in silicosis of rats treated by polyvinylpyridine-N-Oxide[J]. Journal of hygiene research, 1995, 0(3) |
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| Authors: | Miao Qing Liu Bingci He Yuxian Wang Haihua et al. |
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| Abstract: | Polyvinylpyridine-N-oxide(PVNO) is a kind of effective anti-silicotic medicine. The authors studied the effect of PVNO on the collagen mRNA levels in silicosis rats. Dot blot results showed that α1(Ⅰ) and α1(Ⅲ)mRNA levels increased significantly at 60 and 120 days after the rats exposed to silica dust.The mRNA levels dropped down at 1 and 3 months after treated by PVNO.It is suggested that PVNO may inhibit the expression of collagen gene during silicosis. |
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| Keywords: | silicosis polyvinylpyridine-N-oxide mRNA collagen |
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