Analysis of vascular endothelial growth factor (VEGF) functional variants in rheumatoid arthritis |
| |
Authors: | Rueda Blanca González-Gay M Angel López-Nevot M Angel García A Fernández-Arquero M Balsa Alejandro Pablos J Luis Pascual-Salcedo Dora de la Concha Emilio Gómez González-Escribano M Francisca Martín Javier |
| |
Institution: | Instituto de Parasitología y Biomedicina, Granada, Spain. |
| |
Abstract: | The vascular endothelial growth factor (VEGF) is one of the most important pro-angiogenic mediators related to inflammation-associated synovial angiogenesis. The aim of this study was to asses the role of -1154 G-->A (rs1570360) and -634 G-->C (rs2010963) VEGF gene functional variants with rheumatoid arthritis (RA). The population under study was composed of a total of 753 unrelated RA patients and 801 healthy controls. The VEGF -1154 G-->A and -634 G-->C polymorphism genotyping was performed by real-time polymerase chain reaction technology, using TaqMan 5' allelic discrimination assay. No evidence of association was observed between the -1154 G-->A and the -634 G-->C VEGF polymorphisms, or inferred VEGF haplotypes with RA susceptibility or clinical manifestations. Our results suggest that the analyzed VEGF promoter polymorphisms may not play a relevant role in RA pathogenesis in our population. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |