当归(Angelica sinesis)及其成分阿魏酸钠对小鼠吞噬功能的影响

当归为中医常用的补血活血药之一。设想当归的补血活血可能和增强机体免疫功能有关,故进行本项研究。实验分两部分:(1)给小鼠静脉注射当归16g/kg或阿魏酸钠100～200mg/kg均能显著地促进单核吞噬细胞系统对刚果红的廓清率。(2)给小鼠灌胃阿魏酸钠0.3g/kg或皮下给0.2g/kg能增强腹腔巨噬细胞吞噬鸡红细胞的能力。皮下给当归20g/kg也有增强作用。

THE EFFECT OF DANG-GUI (ANGELICA SINENSIS) AND ITS CONSTITUENT FERULIC ACID ON PHAGOCYTOSIS IN MICE

Male mice weighing 18～22 g were used. The aqueous extract of Angelica sinensis was prepared and sodium ferulate synthesized in our Institue.The clearance function of mononuclear phagocyte system was determined by Gongo red clearance test. The plasma Congo red concentration was decreased after an intravenous injection of Angelica sinensis at a dose of 16 g/kg. A similar effect was observed after intravenous administration of sodium ferulate at dosages of 100～200 mg/kg.The phagocytosis of the peritoneal macrophage in mice was estimated by adding cock red blood cell suspension to the macrophages. The phagocytosis percentage and phagocytosis index were increased when sodium ferulate was given either subcutaneously (0.2 g/kg/day) or orally (0.3 g/kg/day) for 4 days. Angelica sinensis (20g/kg sc)manifested a similar effect.The above results indicate that the phagocytosis function in mice was potentiated by treatment with Angelica sinensis and its constituent, ferulic acid.