血清CA125测定在胸腔积液患者中的临床意义

目的检测不同原因引起的胸腔积液的血清肿瘤标志物CA125(癌胚抗原125)在胸腔积液患者中的临床价值。方法选择130例胸腔积液患者,检测所有患者血清CA125的浓度,分别按照疾病的良恶性、胸水量的大小、渗出液与漏出液分组,比较各组间患者浓度水平的差别。结果 130例胸腔积液患者中有123例血清CA125升高,阳性率为94.62%;恶性胸腔积液组与良性胸腔积液组相比血清CA125浓度有显著性差异(P0.05);大量胸腔积液组与中小量胸腔积液组、渗出液与漏出液之间相比,血清CA125浓度无显著性差异(P0.05)。结论血清CA125可作为鉴别良恶性胸腔积液的重要辅助指标,但其对量的大小及渗出液、漏出液的鉴别无临床应用价值。

Clinical significance of serum CA125 in patients with pleural effusion

Objective To study the concentration of serum CA125 in patients with pleural effusion caused by various diseases, and to explore the clinical value of serum CA125 to patients with pleural effusion. Methods 130 patients were selected, and their serum levels of CA125 were detected. The patients were divided into different groups according benign or malignant, volume, exudate and transudate. The differences of CA125 was analyzed among those groups. Results The serum level of CA125 increased in 123 patients, and the positive rate was 94.62%. The serum level of CA125 in patients with malignant pleural effusion was significantly higher than that in benign pleural effusion （P〈0.05）, but there were no significant difference between large and small intermedia volume of pleural effusion, and exudate and transudate （P〉0.05）. Conclusion The positive rate of serum CA125 in patients with pleural effusion is considerably high, and it can predict that the inspection of serum CA125 has significantly clinical value for the diagnosis and differential diagnosis of pleural effusion. But it has nothing to do with the volume of pleural effusion and exudate and transudate.