大黄酸对果糖诱导的高尿酸大鼠的肾脏保护作用研究 |
| |
引用本文: | 董晓琴. 大黄酸对果糖诱导的高尿酸大鼠的肾脏保护作用研究[J]. 海峡药学, 2016, 0(3): 42-44. DOI: 10.3969/j.issn.1006-3765.2016.03.017 |
| |
作者姓名: | 董晓琴 |
| |
作者单位: | 江苏南京正大天晴制药有限公司南京210038 |
| |
摘 要: | 目的:研究大黄酸对果糖诱导的痛风大鼠的肾脏保护作用。方法通过果糖喂养的方法制备痛风大鼠模型,连续灌胃大黄酸6周,测定血清肌酐、尿素氮、尿酸和黄嘌呤氧化酶含量等指标。结果大黄酸降低大鼠血清肌酐、尿素氮、尿酸和黄嘌呤氧化酶含量,改善了果糖诱导的大鼠肾脏结构的变化。结论大黄酸对果糖诱导的痛风大鼠具有肾脏保护作用。
|
关 键 词: | 大黄酸 果糖 高尿酸 肾脏保护 |
Protection of Rhein on Kidney Injury in Fructose-induced Hyperuricaemia Rats |
| |
Abstract: | OBJECTIVE This study was to investigate the protective effects of rhein on renal injury in fructose-induced hyperuricaemia rats.METHODS SD male rats were given 10%fructose in drinking water for 4 weeks to induce hyperuricemia,rhein (10,20 and 40mg? kg -1 ) daily for next 6 weeks,respectively.Serum levels of uric acid,creatinine,blood urea nitrogen,and xanthine oxidase were measured.RESULTS Rhein significantly decreased serum levels of uric acid,creatinine,blood urea nitrogen,and xanthine oxidase.CONCLUSION Rhein alleviates kidney injury in fructose-induced hyperuricaemia rats. |
| |
Keywords: | Rhein Fructose Hyperuricaemia Renoprotection |
本文献已被 万方数据 等数据库收录! |
|