10 d序贯疗法与标准三联疗法根除幽门螺杆菌疗效比较

目的：比较10 d序贯疗法与标准三联疗法根除幽门螺杆菌的临床疗效。方法选取2015年6月至2016年6月在我院内科接受治疗的100例幽门螺旋杆菌阳性消化性溃疡患者作为研究对象，按照随机数表法将所有患者分为观察组和对照组，每组50例，观察组患者给予10 d序贯疗法治疗，对照组患者给予标准三联疗法，比较两组患者治疗后不良反应的发生率、症状缓解时间、住院费用和Hp清除率情况。结果治疗后，观察组患者的Hp清除率为96.00%，略高于对照组的90.00%，但两组比较差异无统计学意义(P>0.05）；治疗后，观察组患者的失眠、口苦、恶心、食欲不佳、腹泻、头晕、皮疹以及嗜睡等不良反应发生率均明显低于对照组，两组比较差异均具有统计学意义(P<0.05)；治疗后观察组患者的腹部疼痛缓解时间和消化道症状缓解时间分别为(2.13±0.32) d和(2.89±0.45) d，均明显的短于对照组的(3.26±0.19) d和(4.31±1.02) d，住院费用为(2348.26±312.56)元，低于对照组的(3356.21±317.89)元，两组比较差异均具有统计学意义(P<0.05)。结论与标准三联疗法比较，10 d序贯疗法的根除Hp清除率更高，且不良反应的发生率也较低，患者症状缓解所需时间较短，值得临床推广应用。

Comparative analysis of the clinical efficacy of 10-day sequential therapy and standard triple therapy in Helicobacter pylori eradication

Objective To compare the clinical efficacy of 10-day sequential therapy and standard triple thera-py in the eradication of Helicobacter pylori (Hp). Methods A total of 100 cases of Helicobacter pylori-positive peptic ul-cer patients, who admitted to our hospital for the treatment of Helicobacter pylori-positive peptic ulcer from June 2015 to June 2016, were selected as the subjects of this study and divided into the observation group and the control group ac-cording to the random number table method, with fifty patients in each group. The patients in observation group were treated with sequential therapy for 10 days, and the patients in the control group were treated with standard triple thera-py. The incidence of adverse reactions, symptom remission time, hospitalization cost and Hp clearance rate were com-pared between the two groups. Results After the treatment, the Hp clearance rate of the observation group was 93.33%, which was slightly higher than 88.33%of the control group, but the difference between the two groups was not statistically significant (P>0.05);The incidence of adverse reactions such as insomnia, mouth pain, nausea, poor appe-tite, diarrhea, dizziness, rash and drowsiness in the observation group were significantly lower than those in the control group (P<0.05); the time of relieving time of abdominal pain and digestive tract symptom in the observation group were (2.13 ± 0.32) d and (2.89 ± 0.45) d, respectively, which were significantly shorter than (3.26 ± 0.19) d and (4.31 ± 1.02) in the control group, and the hospitalization cost was (2 348.26±312.56) yuan, which was significantly lower than (3 356.21±317.89) yuan of the control group. The differences between the two groups were statistically significant (P<0.05). Conclusion Compared with standard triple therapy, 10-day sequential therapy has higher eradication rate, lower incidence of adverse reactions and shorter symptom relief time, which is worthy of clinical application.