口服酪酸梭菌活菌片联合小儿速泻停颗粒治疗轮状病毒肠炎疗效观察

目的：观察口服酪酸梭菌活菌片联合小儿速泻停颗粒治疗轮状病毒肠炎(RE)患者的临床疗效。方法选择2015年9月至2016年6月在我院儿科治疗的RE患儿114例纳入研究。依据简单数字随机表法将患儿分成观察组和对照组各57例，两组患儿均予以常规临床治疗措施，给予正常补液和抗病毒治疗，并为患儿纠正其脱水症状和酸碱平衡。对照组在此基础上予以小儿速泻停颗粒治疗，观察组在对照组基础之上另增用酪酸梭菌活菌片治疗，5d后比较两组患儿的疗效、主要症状的缓解时间、不同时期的体液免疫功能相关指标(IgA、IgM及IgG)及细胞免疫相关指标(CD3+、CD4+、CD8+)的差异。结果观察组患儿的治疗总有效率为94.74%(54/57)，明显高于对照组的82.46%(47/57)，差异有统计学意义(P<0.05)；观察组患儿的发热缓解时间、腹泻控制时间及呕吐控制时间均明显少于对照组，差异均有统计学意义(P<0.05)；治疗后观察组患儿的IgG、IgM及IgA水平明显高于对照组，差异均有统计学意义(P<0.05)；治疗后观察组的CD4+及CD4+/CD8+明显低于治疗前与对照组，差异均有统计学意义(P<0.05)。结论酪酸梭菌活菌片联合小儿速泻停颗粒治疗RE患儿能够发挥较好的疗效，同时还能优化其免疫功能，值得临床推广。

Effect of clostridium butyricum tablets combined with infantile diarrhea and stopping granule in the treatment of rotavirus enteritis

Objective To observe the clinical efficacy of clostridium butyricum tablets combined with infantile diarrhea and stopping granule in the treatment of rotavirus enteritis (RE). Methods A total of 114 children with RE, who admitted to our hospital from September 2015 to June 2016, were enrolled in the study and divided into the control group and the observation group according to simple digital random table method, with 57 cases in each group. The chil-dren of the two groups were given conventional clinical treatment measures, the normal rehydration and antiviral thera-py, and their dehydration symptoms and acid-base balance were corrected. On this basis, the control group was treated with infantile diarrhea and stopping granule, and the observation group was treated with additional use of clostridium bu-tyricum tablets based on the control group's treatment. Five days later, the efficacy, the main symptoms of remission time, different periods of humoral immune function related indicators (IgA, IgM and IgG) and cell immune related indi-cators (CD3+, CD4+, CD8+) of the two groups were compared. Results The total effective rate of treatment in the obser-vation group was 94.74% (54/57), which was significantly higher than that 82.46% (47/57) in the control group (P<0.05);the time of fever remission, the control time of diarrhea and vomiting in the observation group were significantly less than those in the control group (P<0.05);after the treatment, the levels of IgG, IgM and IgA in the observation group were significantly higher than those in the control group (P<0.05);after the treatment, the CD4+and CD4+/CD8+of the observation group were significantly lower than those of the control group (P<0.05). Conclusion Clostridium butyri-cum tablets combined with infantile diarrhea and stopping granule has a good curative effect in the treatment of children with RE, which can also optimize the immune function of children. It is worthy of clinical promotion.