直肠癌患者全程心理干预效果评价

目的：探讨全程心理干预对直肠癌患者负性情绪、化疗副反应、生存质量的影响。方法选取2008年2月至2014年11月在我科住院的112例患者作为研究对象，以数字表法随机分为干预组和非干预组，每组各56例。干预组患者进行全程心理干预，非干预组患者除了不进行心理干预外，其他治疗同心理干预组。心理干预前及术后出院前分别采用焦虑自评量表(SAS)、抑郁自评量表(ADS)比较两组患者的焦虑、抑郁评分。心理干预前及干预1年后采用欧洲癌症研究与治疗组织的QLQ-C30核心量表(EORTC QLQ-C30)比较两组患者的生存质量评分。第3周期化疗结束后比较两组患者的化疗副反应。结果干预组与非干预组患者的焦虑评分分别为(42.63±3.66)分和(57.56±4.13)分，抑郁评分分别为(39.85±6.37)分和(56.67±8.35)分，干预组患者焦虑与抑都评分均低于非干预组，差异均有统计学意义(P<0.05)；干预组患者的躯体功能、角色功能等生存质量评分均高于非干预组，差异均有统计学意义(P<0.05)；干预组与非干预组的重度疲乏无力发生率分别为13%和25%，严重恶心呕吐发生率分别为14%和27%，干预组化疗副反应低于非干预组，差异均有统计学意义(P<0.05)。结论直肠癌患者在常规治疗基础上进行全程心理干预能有效降低患者的负性情绪，明显改善患者的生存质量，减轻化疗的副反应，值得临床推广。

Effect of whole course psychological intervention in patients with rectal cancer

Objective To explore the influence of the whole course psychological intervention on negative emotion, side effect of chemotherapy and the quality of life in patients with rectal cancer. Methods A total of 112 pa-tients with rectal cancer in our department from February 2008 to November 2014 were selected as the research sub-jects, which were randomly divided into intervention group and non-intervention group based on the digital table meth-od, with 56 patients in each group. Patients in the intervention group received whole course of psychological interven-tion, and patients in the non-intervention group did not receive psychological intervention with other treatments the same. Self-rating anxiety scale (SAS) and Self-rating Depression Scale (SDS) were used to compare the scores of anxi-ety and depression between the two groups before the psychological intervention and before discharge. The scores of quality of life were compared between two groups before the psychological intervention after 1 year of psychological intervention by European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30). Results The scores of anxiety in the intervention group and the non-intervention group were (42.63 ± 3.66) and (57.56 ± 4.13), and the scores of depression were (39.85 ± 6.37) and (56.67 ± 8.35), respectively. The scores of anxiety and depression in the intervention group were significantly lower than those in the non-intervention group (P<0.05). The scores of physical function, role function and other scores of quality of life in the intervention group were significantly higher than those in non-intervention group, and the differences were statistically significant (P<0.05). The incidence of severe fatigue and weakness in the intervention group and the non-intervention group were 13%and 25%, respectively. The incidence of severe nausea and vomiting were 14%and 27%, respectively. The adverse reaction of chemotherapy in the intervention group was lower than that in the non-intervention group, and the difference was sta-tistically significant (P<0.05). Conclusion The whole course psychological intervention on the basis of routine treat-ment can reduce the patient's negative emotions, significantly improve the quality of life of patients, and reduce the side effects of chemotherapy, which is worth to clinical promotion.