临床药师以用药教育为核心的药学干预对癌痛和化疗的影响

目的：探讨临床药师以用药教育为核心的药学干预在癌症患者癌痛和化疗中的作用。方法选择2013年5月至2015年5月我院肿瘤内科收治的癌痛患者70例，采用随机数字法分为观察组和对照组各35例。对照组患者仅给予常规化疗，观察组患者在此基础上，由临床药师以用药教育为核心进行药学干预。干预后1个月，比较两组患者的治疗效果、使用止痛药以及对癌痛和止痛知识的了解情况，并评价两组患者的疼痛强度，记录两组患者的生活质量疼痛影响评分。结果观察组患者化疗的总有效率为88.6%(31/35)，明显高于对照组的68.6%(24/35)，差异有统计学意义(P<0.05)；观察组使用止痛药患者占42.9%(15/35)，明显低于对照组的71.4%(25/35)，差异有统计学意义(P<0.05)；观察组患者对癌痛知识和止痛知识的了解评分分别为(8.2±1.5)分和(8.0±1.1)分，明显高于对照组的(5.3±2.4)分和(5.8±1.8)分，差异均具有统计学意义(P<0.05)；与对照组第2次比较，观察组在最严重疼痛强度、当前疼痛强度、活动时疼痛强度方面评分均显著降低，差异均具有统计学意义(P<0.05)。此外，观察组疼痛影响生活质量的各项评分亦均显著低于对照组差异均具有统计学意义(P<0.05)。结论临床药师对癌痛患者实施以用药教育为核心的药学干预，在化疗效果、癌症疼痛强度以及生活质量方面均有积极的意义。

Influence of medication-education-oriented pharmaceutical intervention by clinical pharmacist on cancer pain and chemotherapy of patients

Objective To investigate the influence of medication-education-oriented pharmaceutical interven-tion by clinical pharmacist on cancer pain and chemotherapy of patients. Methods A total of 70 patients with cancer pain, who admitted to Department of Medical Oncology in our hospital from May 2013 to May 2015, were enrolled and randomly divided into the observation group (n=35) and the control group (n=35) according to random number ta-ble. The control group was given conventional chemotherapy, on which basis, the observation group was conducted with medication-education-oriented pharmaceutical intervention by clinical pharmacist. After one month, the therapeu-tic effects, the use of painkiller, and the patients' understanding of cancer pain and painkilling knowledge were com-pared between the two groups. Pain intensity and cancer pain influencing life quality in the two groups were assessed. Results The total effective rate in the observation group 88.6%(31/35) was significantly higher than that in the con-trol group 68.6%(24/35), P<0.05. The rate of patients' uses of painkiller in the observation group 42.9%(15/35) was sig-nificantly lower than that in the control group 71.4%(25/35), P<0.05. The scores of understanding of cancer pain and painkilling knowledge in the observation group ((8.2±1.5) points, (8.0±1.1) points, respectively) were significantly high-er than those in the control group ((5.3 ± 2.4) points, (5.8 ± 1.8) points, respectively), P<0.05. Compared with the control group at the second time, the scores of worst pain intensity, current pain intensity, and pain intensity at activity in the ob-servation groups decreased significantly (P<0.05). Additionally, all scores of cancer pain influencing life quality in the observation group were obviously lower than those in control group, and the differences were statistically different (P<0.05). Conclusion Medication-education-oriented pharmaceutical intervention by clinical pharmacist is of positive sig-nificance to improving the chemotherapeutic effects, reducing the cancerous pain intensity, and enhancing the quality of life of patients.