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大黄酸肠溶片的制备
引用本文:童敏,谭梅英,朱永坤,詹利之. 大黄酸肠溶片的制备[J]. 海峡药学, 2016, 0(6): 7-9. DOI: 10.3969/j.issn.1006-3765.2016.06.003
作者姓名:童敏  谭梅英  朱永坤  詹利之
作者单位:1. 东莞市第三人民医院 东莞 523326;2. 广东省第二中医院 广州510095;3. 广州中医药大学青蒿研究中心广州510405
摘    要:目的:研制大黄酸肠溶片。方法采用正交试验设计法,以包衣效率为指标,考察雾化压力、蠕动泵转速、枪床距离3个因素,优化大黄酸肠溶片的包衣工艺。结果最佳工艺参数,雾化压力4.5kg/cm2、蠕动泵转速1.5mL? min -1、枪床距离30cm。结论所制备的肠溶片符合设计要求,适合临床应用。

关 键 词:大黄酸  肠溶片  制备工艺

Preparation of Rhein enteric Coated TabIets
Abstract:OBJECTIVE To study the preparation of rhein enteric coated tablets .METHODS Orthogonal ex-periment design was used to optimize the process of preparation , and atomization pressure , peristaltic pump speed , distance between spray gun and pan were investigated .RESULTS The optimal technical conditions were as fol-lows:atomization pressure 4.5kg/cm2 ,peristaltic pump speed 1.5mL? min -1 ,distance between spray gun and pan 30 cm.CONCLUSION The enteric coated tablets comply with the design requirement ,and suitable for clinical ap-plication.
Keywords:Rhein  Enteric coated tablets  Preparation technology
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