Cytotoxic diterpenes from Scoparia dulcis |
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| Authors: | Ahsan Monira Islam S K N Gray Alexander I Stimson William H |
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| Affiliation: | Department of Pharmacy and Institute of Nutrition and Food Science, University of Dhaka, Dhaka-1000, Bangladesh. monira@smpt.udhaka.net |
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| Abstract: | Four new labdane-derived diterpenes, iso-dulcinol (1), 4-epi-scopadulcic acid B (2), dulcidiol (4), and scopanolal (5), together with two known diterpenes, dulcinol/scopadulciol (3) and scopadiol (6), were isolated from the aerial parts of Scoparia dulcis. The structures were determined by extensive NMR studies. The crude extracts as well as the pure diterpenes showed cytotoxicity against a panel of six human stomach cancer cell lines. |
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