人脑胶质瘤中Survivin、Ki-67的表达及其临床意义

目的探讨Survivin和Ki-67抗原在人脑胶质瘤中的表达及其临床意义。方法应用免疫组化SP法检测10倒正常脑组织和68例人脑胶质瘤中Survivin和Ki-67的表达。结果Survivin和Ki-67在正常脑组织中均不表达，而在各级别的人脑胶质瘤中均有表达，差异极显著（P％0.01），Survivin和Ki-67的表达在高级别胶质瘤中显著高于低级别胶质瘤（P％0．01），且Survivin和Ki-67的表达呈显著正相关（P〈0．05）。结论Ki-67可以作为评估胶质瘤细胞增殖的良好指标，Survivin和Ki-67的表达可以判断胶质瘤的恶性程度，为临床病理分级提供有意义的依据。

Expression of Survivin and Ki-67 in human glioma and their clinical significance

Objective To study Survivin and Ki-67 antigens expression in human glioma and their significance.Methods The expression of Survivin and Ki-67 were detected in 68 cases of humen glioma and 10 specimens of normal brain tissue by immunohistochemical staining(SP methods).Their clinical significance and the correlation between the Survivin and Ki-67 were analyzed.Results The Survivin and Ki-67 were not expressed in all the normal brain tissue,but the expression of Survivin and Ki-67 could be detected in all the grades of gliomas.There were significant difference in the expression of Survivin and Ki-67 among the normal brain tissue group,the low grade gliomas group and high grade gliomas group(P<0.01).There was a significantly positive correlation(P<0.05)between the expression of Survivin and Ki-67 and histological grade of human glioma.Conclusion The expression of Survivin and Ki-67 are helpful to judging malignant degree of human glioma and its pathological grade.The expression level of Ki-67 may be a helpful index of proliferation of the glioma cell.