中国发热伴血小板减少综合征布尼亚病毒致病性研究进展

发热伴血小板减少综合征布尼亚病毒(SFTSV)隶属于布尼亚病毒科白蛉病毒属,近年来已在中国十余省市发生了蜱叮咬感染该病毒病例,至数十人死亡。SFTSV病毒颗粒呈球形,主要分布在感染细胞的微粒体,表面有棘突,其基因组由大、中、小3个单股负链RNA片段组成,分别编码RNA聚合酶,病毒膜蛋白和非结构蛋白。感染后临床表现为发热、恶心呕吐,多数患者很快出现外周血血小板减少,肝肾等器官功能受损等症状。本文综述了新型布尼亚病毒病原学、所致疾病、感染和免疫应答以及检测的国内外研究进展,为该病毒感染的早期快速诊断、对症治疗和疾病预防等工作提供参考。

Pathogenicity of severe fever with thrombocytopenia syndrome bunyavirus in China:an overview

Studies have ascertained that "tick bite event" occurring in more than ten provinces and leading to dozens of deaths in China in recent years was a human infectious disease caused by severe fever with thrombocytopenia syndrome bunyavirus(SFTSV).SFTSV particles are spherical with surface spines, and mainly distribute in the microsomes of the infected cells.The genome of the virus is consisted of three(large, medium and small) single strand RNA negative chains, coding RNA polymerase, virus membrane protein and non-structure protein, respectively.The clinical manifestations of SFTSV infection are fever, nausea, vomiting, rapid decrease of peripheral blood platelet in most of the infected cases, and damage of liver, kidney and other organ.This review focused on the research progress in China and abroad on the etiology, relevant diseases, immune response, and detection of SFTSV to provide reference for early diagnosis and prevention of Bunia virus.