福建省性传播艾滋病病毒感染者/艾滋病病人生存状况分析

目的 分析福建省性传播艾滋病病毒感染者（HIV）/艾滋病病人（AIDS）生存状况及其影响因素。方法 利用中国疾病预防控制信息系统艾滋病综合防治信息系统，收集自1987年福建省报告首例经性传播病例-2014年11月30日病例基本信息和随访资料，采用回顾性队列研究分析相关数据。结果 6 146例研究对象平均生存时间为（189.91±7.58）月，中位生存时间216月；首次确诊HIV抗体阳性时年龄<50组死亡风险低于年龄≥50岁组（P均<0.0001）；大专以上文化程度病例死亡风险低于其他文化水平患者（95%CI=0.20~0.87，P=0.020），重点人群、羁押人群发现病例死亡风险低于医疗机构发现病例（P分别为0.010、0.046）；CD4⁺T淋巴细胞≤500个/μL病例死亡风险高于CD4⁺T淋巴细胞>500个/μL病例（P均<0.000 1，95%CI=19.04~83.03、6.17~28.33、1.89~8.26）；未治疗组死亡风险高于治疗组（P<0.000 1，95%CI=4.12~7.21）。结论 年龄、文化程度影响HIV/AIDS的生存时间。

Survival of HIV/AIDS infections via sexual transmission in Fujian province

Objective To analyze the survival time and its related factors among human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)infections vial sexual transmission in Fujian province.Methods A retrospective cohort study was conducted to collect data on sexually transmitted HIV/AIDS cases from 1997 through 31 November,2014 in Fujian province.Records and follow-up data of the HIV/AIDS cases were extracted from China Information System for HIV/AIDS Control and Prevention and analyzed with SPSS 15.0.Results For a total of 6 146 HIV/AIDS cases registered during the period,the mean survival time was 189.91±7.58 months and the median survival time was 216 months.Multivariate Cox regression showed that the HIV/AIDS cases aged <50 years at the first diagnosis had a lower mortality risk than those ≥50 years (P<0.001);the cases with the education of college or above had a lower mortality risk than those with the education of other level (odds ratio[OR]=0.41,95% confidence interval:[95% CI]:0.20-0.87);the cases identified among high-risk or detained populations were at a lower mortality risk than those identified among attendances of medical institutions (both P<0.05);the cases with lower CD4⁺ T cell count of ≤500/μL at the first detection had a higher mortality risk than those with the count of >500/μL (all P<0.001);and the cases without treatment had a higher mortality risk than those with treatment (OR=5.45,95% CI:4.12-7.21).Conclusion The survival time of sexually transmitted HIV/AIDS patients in Fujian province is mainly influenced by their age,education level,and medical treatment.