广州市艾滋病外籍病例及耐药分析

目的 了解并分析广州市历年报告的艾滋病（AIDS）外籍病例流行特征及部分病毒耐药性情况。方法 对1990-2013年报告的AIDS外籍病例及2008-2010年新确证外籍艾滋病病毒（HIV）感染者基因耐药性检测结果进行分析。结果 广州市1990-2013年累计报告外籍AIDS病例644例；国籍明确者中最多为非洲籍（36.6%），男性为主（62.9%），平均年龄为37.3岁，病例类型大多数为HIV感染者（81.7%），AIDS病例所占比例呈逐年增长的趋势；2008-2010年新确证HIV抗体阳性样本总体耐药率为23.33%，集中表现为对奈非那韦（NFV）耐药。结论 应加强广州市外籍人群的HIV检测工作，为该人群提供随访治疗等服务，减少流行及耐药毒株向本地传播风险。

Incidents of HIV infection and HIV drug-resistance among foreigners in Guangzhou city

Objective To examine incident characteristics of human immunodeficiency virus (HIV) infection and HIV drug-resistance among foreigners in Guangzhou city.Methods Information about foreigners infected with HIV reported from 1990 through 2013 and the data on HIV drug-resistance in foreign HIV infection cases initially identified during 2008 and 2010 were collected and analyzed.Results A total of 644 HIV positive foreigners were reported in Guangzhou during a 24-year period;62.9%of the cases were males and the average age of the cases were 37.3 years;more than one-third (36.6%) of the cases were from Africa.Though the majority of the cases presenting no AIDS symptoms,the proportions of clinic AIDS increased among the reported cases during the period.The prevalence of resistance to any anti-HIV drug was 23.33%among the newly confirmed HIV positive foreigners from 2008 to 2010 and the proportion of nelfinavir resistance was the highest.Conclusion Surveillance on HIV infection should be enhanced among foreigners in Guangzhou city for the control of HIV epidemic and transmission of drug-resistant HIV strains.