自噬性细胞死亡及其与细胞凋亡、坏死关系研究进展

正常水平的自噬是一种通过降解细胞内异常组分以维持细胞稳态的过程，然而自噬水平过度上调则引起细胞自噬性死亡；虽然，在生化代谢与形态学方面，自噬性细胞死亡与另两种细胞死亡形式-凋亡和坏死有明显的差别，但是，越来越多的研究表明这三者之间有着密切的联系；因而对于自噬及其和凋亡、坏死之间关系的深入研究对相关疾病的认识和治疗具有相当重要的意义。

Progress in researches on autophagic cell death and its relationship with apoptosis and necrosis

Autophagy is a highly regulated intracellular degradative process by which cells remove cytosolic long-lived proteins and damaged organelles.Although autophagy is regarded as a regular degradative process maintaining cellular homeostasis,this process also represents one mode of programmed cell death.Although there are significant differences between autophagic cell death,apoptosis and necrosis in the metabolic and morphologic changes,it is revealed that there are extensive crosstalks in autophagic cell death,apoptosis and necrosis.Therefore,it is important to investigate the relationship obetween autophagy,apoptosis and necrosis to provide clues for effective prevention and treatment of relevant diseases.