| 强迫游泳应激强度的改变对大鼠海马中c—fos表达习惯化的影响 |
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| 引用本文： | 马慧 王大鹏 丁宝坤 金魁和. 强迫游泳应激强度的改变对大鼠海马中c—fos表达习惯化的影响[J]. 中国行为医学科学, 2003, 12(2): 125-127 |
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| 作者姓名： | 马慧 王大鹏 丁宝坤 金魁和 |
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| 作者单位： | [1]中国医科大学精神医学教研室，辽宁沈阳110001 [2]中国医科大学发育生物学研究室 |
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| 摘 要： | 目的 研究应激强度的改变对重复应激导致的大鼠海马中c—fos表达习惯化的影响。方法 采用特异抗体的免疫组织化学方法，在重复强迫温水游泳应激导致的c—fos表达习惯化大鼠模型基础上，观察强迫冰水游泳应激对大鼠海马中c—fos表达的影响。结果 重复强迫温水游泳应激导致c—fos表达习惯化后，再给予强迫冰水游泳应激使c—fos表达水平再次升高。结论 高强度的应激可以逆转低强度应激所引起的习惯化效应。
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| 关 键 词： | 强迫游泳 应激强度 习惯化 c－fos 基因表达 |
| 文章编号： | 1005-8559(2003)02-125-03 |
| 修稿时间： | 2002-05-28 |
Impact of change of stress intensity on the habituation of the expression of immediate early gene c-fos in the rat hippocampus |
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| MA Hui,WANG Da peng,DING Bao kun. Impact of change of stress intensity on the habituation of the expression of immediate early gene c-fos in the rat hippocampus[J]. Chinese Journal of Behavioral Medical Science, 2003, 12(2): 125-127 |
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| Authors: | MA Hui WANG Da peng DING Bao kun |
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| Affiliation: | MA Hui,WANG Da peng,DING Bao kun.Department of Psychiatry,China Medical University,Shenyang 110001 |
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| Abstract: | Objective To study the impact of change of stress intensity on the habituation of the expression of c fos within the hippocampus of repeated forced swimming rats. Method After repeated forced swimming in warm water, rats were forced to swim in cold water and the expression of c fos within the hippocampus was observed by the immunohistochemical method. Results Repeated forced swimming in warm water resulted in habituation of the expression of c fos, and an additive forced swimming in cold water led to a higher level of the expression of c fos. Conclusion Stress of high intensity can reverse the habituation resulted from repeated stress of low intensity. |
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| Keywords: | Forced swimming Stress intensity Habituation c fos |
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