2001—2011年我国出生缺陷影响因素的系统分析

目的探讨我国2001—2011年间出生缺陷的影响因素,为下一步的预防提供科学依据。方法利用Meta分析的方法系统评价2001—2011年间公开发表的有关我国出生缺陷影响因素的24篇文献。结果出生缺陷影响因素的合并比值比(OR值)及95%CI分别为孕期感冒发热2.00(1.46～2.73),孕期接触有害化学物质2.02(1.51～2.71),居住地有污染源1.86(1.26～2.73),孕期接触农药史1.80(1.08～2.99),孕期服用抗生素等药物1.65(1.37～1.98),自然流产史1.64(1.13～2.38),有生育畸形儿史1.61(1.30～2.01),父亲接触有害化学物质1.51(1.08～2.11),孕期弓形体病、其他病毒、风疹、巨细胞病毒、单纯疱疹病毒(TORCH)感染1.44(1.10～1.88),产次≥2次1.41(1.00～2.01),负性事件刺激1.11(1.04～1.19)。结论孕期感冒发热、孕期接触有害化学物质、孕期服用抗生素等药物、孕期负性事件刺激、孕期接触农药史、父亲接触有害化学物质、自然流产史、有生育畸形儿史、产次≥2次、居住地有污染源、孕期TORCH感染等是出生缺陷的影响因素。

Systematic analysis of influencing factors of birth defects in China during 2001-2011

[Objective]To investigate the influencing factors to birth defects in Chinese population during 2001-2011,and provide scientific evidence for birth defects prevention.[Methods]Meta-analysis was adopted to systematically evaluate 24 papers published during 2001-2011 about the influencing factors of birth defects in China.[Results] The pooled OR values and 95% CI were as follows： prenatal common cold and fever 2.00（1.46-2.73）;exposure to toxic chemical materials in pregnancy 2.02（1.51-2.71）;pollution sources in apartment 1.86（1.26-2.73）;exposure to pesticides in pregnancy 1.80（1.08-2.99）;taking antibiotic and other medicine in pregnancy 1.65（1.37-1.98）;spontaneous abortion history 1.64（1.13-2.38）;bearing malformation child history 1.61（1.30-2.01）;paternal exposure to toxic chemical materials 1.51（1.08-2.11）;infections of TORCH in pregnancy 1.44（1.10-1.88）;parity≥2,1.41（1.00-2.01）;negative life events stimulus in pregnancy 1.11（1.04-1.19）.[Conclusion]The factors influencing the incidence of birth defects are prenatal common cold and fever in pregnancy,exposure to toxic chemical materials in pregnancy,taking antibiotic and other medicine in pregnancy,negative life events stimulus in pregnancy,exposure to pesticides in pregnancy,paternal exposure to toxic chemical materials,spontaneous abortion history,bearing malformation child history,parity≥2,pollution sources in living place,infections of TORCH in pregnancy and so on.