不稳定型心绞痛患者早期大剂量他汀类药物治疗对血清超敏C-反应蛋白的影响

目的探讨不稳定型心绞痛(UAP)患者早期接受大剂量他汀类药物治疗对血清超敏C-反应蛋白(Hs-CRP)的影响及其临床意义。方法将78例UAP患者随机分为治疗组41例和对照组37例,两组患者入院后均常规予阿司匹林、氯吡格雷、美托洛尔、低分子肝素及硝酸酯类药物治疗,治疗组的患者同时接受口服辛伐他汀40mg/d,1周后比较两组患者血清Hs-CRP水平的变化。结果治疗组患者治疗前、后血清Hs-CRP水平间差异有统计学意义(P<0.05),且两组患者治疗后血清Hs-CRP水平间差异亦有统计学意义(P<0.05)。结论早期接受大剂量他汀类药物治疗可以迅速降低UAP患者血清CRP水平,从而抑制体内的炎症反应,UAP患者应尽早接受大剂量他汀类药物治疗。

Effect of Early High-dose Statin Therapy on the Serum High Sensitivity C-reactive Protein (Hs-CRP) in the Patients with Unstable Angina Pectoris (UAP)

Objective To evaluate the effect of early high-dose statin therapy on the serum Hs-CRP in the patients with UAP.Methods 78 patients with UAP were divided into the therapy group(n=41)and the control group(n=37)randomly.All the patients were treated with conventional drugs such as aspirin,clopiclogrel,metoprolol,low moleculer weigh heparin and nitrate,and the patients from the therapy group received simvastatin(40mg/day)at the same time.The levels of Hs-CRP were measured at baseline and after 7 days of therapy.Results The levels of the serum Hs-CRP decreased significantly in the therapy group(P<0.05),and the change of the serum Hs-CRP concentration in the therapy group was higher than in the control group(P<0.05).Conclusion Early high-dose statin treatment can rapidly decrease the serum level of CRP in patients with UAP.This may explain why short-term statin therapy can inhibit inflammation in patients with UAP.The patients with UAP should receive high-dose statin therapy as early as quickly.