Effect of Thyroxin on Behavior of Mice with Inherited Difference in Predisposition to Catalepsy |
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| Authors: | E A Zubkov and A V Kulikov |
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| Institution: | (1) Novosibirsk State University, Novosibirsk, Russia;(2) Laboratory for Neurogenomics of Behavior of the Institute of Cytology and Genetics of the Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia |
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| Abstract: | We studied effects of chronic thyroxin administration (2 mg/l, for 60 days) on motor activity, anxiety and depression-like
behavior in cataleptic (ASC/Icg) and non-cataleptic (AKR/J) strains of mice. No effects of thyroxin on anxiety indicators
in “open field” and “light/dark” tests were revealed in mice of the strains under study. At the same time, thyroxin increased
moveability in the “open field” test in AKR/J mice and produced an antidepressant effect in the “forced swimming” test in
animals from ASC/Icg strain. Obtained results are indicative of the role of inherited predisposition to catalepsy in determining
the sensitivity to thyroid hormones.
Translated from Byulleten’ Experimental’noi Biologii I Meditsiny, Vol. 147, No. 2, pp. 177-180, February, 2009 |
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| Keywords: | thyroxin open field light/dark forced swimming mice |
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