Cerebral pathology in the very low birthweight infant: predictive value of peripartum metabolic acidosis.

One-hundred-and-three infants with a birthweight of less than 1500 g and delivering at a gestation of less than 32 weeks were examined by serial cranial ultrasound scans. A capillary blood sample was drawn for blood gas analysis within 1 h of birth in all cases. The subsequent development of intracranial pathology was found to be significantly associated with gestation at delivery (P less than 0.01), birthweight (P less than 0.01) and base deficit within 1 h of birth (P less than 0.001). For infants with a base deficit of greater than 5.0 mmol/l within the first hour of life, the sensitivity for predicting the subsequent development of cerebral pathology was 51.5% with a specificity of 97.3%, and a positive predictive value of 97.1%. This relationship between a metabolic acidosis within 1 h of birth and the subsequent development of cerebral pathology held for both major and minor degrees of pathology, but was stronger in those infants developing major cerebral pathology. The study suggests that improved surveillance of the very preterm infant during labour and at birth with the aim of reducing the incidence of metabolic acidosis at birth, may help to reduce subsequent intracranial pathology, and thereby perinatal and long-term morbidity.