| 氧化修饰引起脂蛋白(a)结构和生化特性变化 |
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| 引用本文： | 汪俊军,庄一义,张春妮. 氧化修饰引起脂蛋白(a)结构和生化特性变化[J]. 医学研究生学报, 1997, 0(4) |
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| 作者姓名： | 汪俊军 庄一义 张春妮 |
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| 作者单位： | 南京军区南京总医院解放军医学检验中心!南京210002 |
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| 摘 要： | 目的 :研究体外丙二醛 ( MDA)、铜离子 ( Cu2 +)氧化修饰脂蛋白 ( a) [L p( a) ]结构和生物学性质的变化。 方法与结果 :氧化修饰 L a( a)过氧化程度增高 ,负电荷增加 ,易被巨噬细胞——清道夫受体识别和摄取。MDA修饰 Lp( a)出现新的 MDA- L DL位点 ;同纤维蛋白溶酶原 ( Pg)竞争抑制试验显示氧化、修饰 Lp( a)同 Pg同源性增加。 结论 :提示载脂蛋白 ( a)状态与动脉粥样硬化的病理过程有关
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| 关 键 词： | 脂蛋白(a) 氧化修饰 纤溶酶原 动脉粥样硬化 |
Modification of Lp(a) causes changes in the structure and biological properties of Lp(a) |
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| Wang Junjun,Zhuang Yiyi,Zhang Chunni. Modification of Lp(a) causes changes in the structure and biological properties of Lp(a)[J]. Bulletin of Medical Postgraduate, 1997, 0(4) |
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| Authors: | Wang Junjun Zhuang Yiyi Zhang Chunni |
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| Affiliation: | Wang Junjun,Zhuang Yiyi,Zhang Chunni Department of Biochemistry,Jinling H ospital |
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| Abstract: | Objectives:To observe changes in the structure and the biological properties of modified L p(a) by Cu2 +or malondialdehyde(MDA) in vitro. Meth- ods and Results:Modified Lp(a) showed enhanced lipid peroxidation and increased negative charge,which can be recognized and uptaken by macrophage- scavenger re- ceptor easily.New epitope was formed upon MDA modified L p(a) .Modified Lp(a) caused significantchange in apo(a) conformation and increased the immuno- reactiv- ity to plasminogen antibody. Conclusions:The state of Apo(a) may be related tothe pathological procedure of atherosclerosis. |
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| Keywords: | Lipoprotein(a) Modification Plasminogen Atherosclerosi |
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