抗HCV阳性的各类肝病患者HCV-RNA、抗-GOR及其与ALT关系

目的: 观察HCV感染者抗-GOR、HCV-RNA及其与丙氨酸氨基转移酶(ALT)的关系。方法: 对69例抗-HCV阳性的慢性丙型肝炎、肝硬化、肝癌患者检测HCV-RNA、抗-GOR水平,并与ALT水平进行比较。结果: 慢性丙型肝炎、肝硬化、肝癌患者HCV-RNA阳性率分别为59.4%、61.9%和56.3%;抗-GOR的阳性率分别为71.9%、66.7%和68.8%。ALT>40 u/L组与ALT ≤ 40 u/L组抗-GOR和HCV-RNA阳性率均有显著性(P<0.005和P<0.05)。结论: 抗-GOR检测有助于HCV的诊断,抗GOR阳性率与ALT水平相关。

Relationship between HCV-RNA,anti-GOR and ALT in Hepatitis with anti-HCV positive

Objective: To observe the relationship between HCV-RNA,anti-GOR and alanine arninotransber(ALT) in patients with various hepatic diseases resulted from HCV.Serum HCV-RNA,anti-GOR and ALT levels of 69 cases of various hepatic diseases with anti-HCV positive were measured and compared.Methods: Anti-HCV and anti-GOR were measured by ELISA and HCVRNA was determined by PCR.Results: The positive rates of HCV-RNA and anti-GOR were 59.4%,61.9%,56.3% and 71.9% 66.7%,(68.8%) respectively in the patients with chronic hepatitis C,hepatocirrhosis,and hepatocellular carcinoma.The positive rate of anti-GOR was significantly higher in the ALT>40 u/L group than that in the ALT ≤ 40 u/L group(P<0.005 and P<0.05).Conclusions: Detection of anti-GOR is of value for the diagnosis of HCV.The positive rate of anti-GOR correlates with the activity of ALT.