Electrocatalytic activity of thianthrene toward one-electron oxidation of guanosine and DNA in a non-aqueous medium |
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Authors: | Masoud A Mehrgardi Abbas Barfidokht |
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Institution: | 1. Chemistry Department, University of Isfahan, Isfahan 81746-73441, Iran;2. Chemistry Department, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45195, Iran |
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Abstract: | In this study, the electrochemical behavior of thianthrene (TH) and its application toward the electrocatalytic oxidation of guanosine (Gs) and DNA in a non-aqueous solution are investigated using different voltammetric techniques. Guanosine and DNA are adsorbed on the glassy carbon electrode (GCE) by applying a positive potential to the GCE. The rate constant of catalytic reaction between DNA and TH and also between Gs and TH were evaluated using chronoamperometry which gave rate constants of 2.41 × 106 cm3 mol−1 s−1 and 2.68 (±0.19) × 106 cm3 mol−1 s−1, respectively. Also the diffusion coefficient of TH was obtained using hydrodynamic voltammetry (3.17 × 10−5 cm2 s−1). Furthermore, using hydrodynamic voltammetry, a one-electron mechanism for oxidation of Gs is suggested. |
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Keywords: | Electrocatalytic oxidation DNA Guanosine Thianthrene Non-aqueous media |
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