Critical flicker frequency fails to disclose brain dysfunction in patients with primary biliary cirrhosis |
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Authors: | Ewa Wunsch Micha? Post Krzysztof Gutkowski Wojciech Marlicz Barbara Szymanik Marek Hartleb Piotr Milkiewicz |
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Institution: | 1. Liver Unit, Pomeranian Medical School, Szczecin, Poland;2. Department of Gastroenterology and Hepatology, Medical University of Silesia, Katowice, Poland;3. Departament of Gastroenterology, Pomeranian Medical School, Szczecin, Poland;4. Department of Electrical and Computer Engineering, West Pomeranian University of Technology, Szczecin, Poland |
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Abstract: | BackgroundRecent studies suggest that stage-independent symptoms of primary biliary cirrhosis (PBC) such as chronic fatigue are a consequence of structural and functional abnormalities of the brain. Critical flicker frequency (CFF) is a psychophysiological modality analysing function of cerebral cortex.AimTo analyse the usefulness of CFF in detection of brain dysfunction in patients with PBC.MethodsFifty-one (37 non-cirrhotic/14 cirrhotic) patients with PBC were included. Control group consisted of 31 matched healthy individuals. Fatigue and health-related quality of life (HRQoL) were assessed using Fatigue Impact Scale (FIS) and questionnaire PBC-40. CFF was analysed with HEPAtonorm Analyzer®.ResultsWhen compared to healthy controls all patients with PBC showed significantly impaired HRQoL in majority of PBC-40 domains and increased fatigue level in physical domain of FIS. No differences in HRQoL and PBC-40 domains were seen, when patients with and without cirrhosis where compared. CFF analysis showed no difference between healthy controls and patients with PBC. CFF did not correlate with PBC-40 and FIS domains.ConclusionCFF fails to determine brain dysfunction in non-encephalopatic patients with PBC, suggesting that functional efficiency of their cerebral cortex remains unaffected and other central mechanisms are responsible for chronic fatigue in these patients. |
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Keywords: | Chronic fatigue Fatigue Impact Scale Health-related quality of life PBC-40 |
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