无痛结肠镜前聚乙二醇口服时间对肠道准备效果的影响

目的观察无痛肠镜术前不同时间口服复方聚乙二醇电解质散剂进行肠道准备的清肠效果和舒适性。方法收集消化内科住院期间173例行无痛结肠镜检查患者的资料,根据口服复方聚乙二醇电解质散剂的时间不同分为3组,A组检查前1天22:00服用4盒,检查时间为当天8∶30~10∶30。B组检查前1天20∶00服用1盒,检查当天5∶00服用3盒,检查时间为当天10∶30~12∶30。C组检查前1天20∶00服用1盒,检查当天7∶00服用3盒,检查时间为当天13∶30~15∶30。比较3组患者结肠准备质量,并评估患者舒适度。结果 A、B和C组结肠准备清洁充分率分别为61.4%、78.7%和72.7%,差异无统计学意义(P=0.111),3组患者主观舒适度比较,B、C组患者肠道准备中舒适度优于A组,不良反应发生率偏低,差异有统计学意义(P=0.036),但B组与C组患者在肠道准备中舒适度差异无统计学意义(P=0.921)。结论无痛肠镜术前3种不同时间口服复方聚乙二醇电解质散剂对肠道清洁度无影响,但分次口服聚乙二醇电解质散剂比单次服用不良反应小,患者容易接受,是比较理想、安全的无痛结肠镜前肠道准备方法。

Effect of oral polyethylene glycol at different time for painless colonoscopy preparation

Objective To compare the efficacy and comfort of oral polyethylene glycol at different time for painless colonoscopy preparation. Methods According to time of oral compound polyethylene glycol electrolyte powder, 173 painless colonoscopy patients were divided into group A, group B and group C. Patients in group A took 4 boxes of compound polyethylene glycol electrolyte powder for colonic preparation at 22:00 on day 1 before the check, the time of painless colonoscopy is 8:30 ~ 10:30. Group B patients took 1 box of compound polyethylene glycol electrolyte powder for colonic preparation at 20:00 on day 1 before the check and took 3 boxes at 5:00 am on check day, the time of painless colonoscopy is 10:30 ~ 12:30. Group C patients took 1 box of compound polyethylene glycol electrolyte powder for colonic preparation at 20:00 on day 1 before the check and took 3 boxes at 7:00 am on check day, the time of painless colonoscopy is 13:30 ~ 15:30. At last, we compare the colon cleanliness and comfort of patients among the three groups. Results There was no significant difference in instetinal cleanliness among the 3 groups (P > 0.05), but there was greatly significant difference in subjective tolerance among 3 groups (P < 0.05). Conclusion The 3 methods of having boxes of compound polyethylene glycol electrolyte power all have the satisfying effect for colonic preparation, but fractionated dose polyethylene glycol electrolyte power provides a better tolerance for bowel preparation of painless colonscopy.