二甲双胍联合妈富隆治疗多囊卵巢综合征临床观察

目的观察二甲双胍联合短效避孕药妈富隆治疗多囊卵巢综合征（PCOS）的疗效。方法选择2006～2008年在我院诊治的多囊卵巢综合征患者49例,随机分成两组。研究组25例给予二甲双胍联合妈富隆治疗,对照组24例单给予妈富隆治疗,用药12周（3个周期）,观察治疗前后临床表现、性激素、空腹血糖和空腹胰岛素等变化。结果两组治疗后痤疮明显改善,月经恢复,血LH、T明显下降（P〈0.01）,LH/FSH比值降低,空腹血糖无变化。单用妈富隆组体重指数和空腹胰岛素无变化。联合用药组体重指数明显降低,空腹胰岛素下降（P〈0.05）,排卵率、妊娠率都较单用妈富隆高,流产率降低。结论采用二甲双胍联合妈富隆对PCOS进行治疗,能有效降低雄激素水平,改善胰岛素抵抗,疗效优于单用妈富隆。

Clinical observation of women with polycystic ovary syndrome treated by combined Marvelon and Metformin

Objective To observe the clinical effects of combined Marvelon and Metformin in the treatment of women with polycystic ovary syndrome(PCOS).Methods 49 weomen with PCOS were randomly divided into 2 groups including Marvelon plus Metformin(n=25 cases,12 weeks,study group) and alone Marvelon(n=24 cases,12 weeks,control group) in 2006-2008.Clinical features,sexual hormone level,fasting blood glucose,fasting insulin were evaluated at baseline and atfer 12 weeks of treatment.Results the serum leutinizing hormone(...