| 七氟烷后处理对大鼠在体心肌缺血再灌注时心肌细胞凋亡的影响 |
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| 引用本文： | 李晓欣,韩冲芳,李婧,杨文曲.七氟烷后处理对大鼠在体心肌缺血再灌注时心肌细胞凋亡的影响[J].中国医疗前沿,2011(2):28-29. |
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| 作者姓名： | 李晓欣 韩冲芳 李婧 杨文曲 |
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| 作者单位： | 山西医科大学第一医院麻醉科; |
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| 摘 要： | 目的研究七氟烷（sevoflurane）后处理对大鼠在体心肌缺血再灌注损伤后细胞凋亡的影响。方法 SD雄性大鼠60只,随机分为5组（n=12）：假手术组（P组）、缺血再灌注组（ischemia-reperfusion,IR组）,小、中、大剂量组（S1、S2、S3组）,建立心肌缺血再灌注模型。光镜下观察各组心肌组织病理变化,检测心肌细胞中Bax、Bcl-2蛋白含量、心肌细胞凋亡指数（AI）。结果与P组相比,IR组、各S组心肌Bax与Bcl-2、AI均显著升高（P〈0.05）,Bcl-2/Bax显著降低（P〈0.05）;与IR组相比,各S组Bax与AI均显著降低（P〈0.05）,Bcl-2与Bcl-2/Bax均显著升高（P〈0.05）;S1组与S3组各指标间无明显差异（P〉0.05）;与S1、S3组相比,S2组Bax与AI均显著降低（P〈0.05）,Bcl-2与Bcl-2/Bax均显著升高（P〈0.05）。结论七氟烷后处理可通过调节Bax与Bcl-2的表达,提高Bcl-2/Bax来发挥心肌保护作用,且中剂量组效果更明显。
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| 关 键 词： | 七氟烷后处理 心肌 缺血再灌注损伤 凋亡 |
Effects of sevoflurane postconditioning on myocardium apoptosis after ischemia reperfusion injury in rats |
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| LI Xiao-xin,HAN Chong-fang,LI Jing,et al..Effects of sevoflurane postconditioning on myocardium apoptosis after ischemia reperfusion injury in rats[J].China Healthcare Innovation,2011(2):28-29. |
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| Authors: | LI Xiao-xin HAN Chong-fang LI Jing |
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| Institution: | LI Xiao-xin,HAN Chong-fang,LI Jing,et al.The First Affiliated Hospital,Shanxi Medical University,Taiyuan 030001,China |
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| Abstract: | Objective To investigate effects of sevoflurane postconditioning on myocardial apoptosis after injury induced by ischema reperfusion of rats in vivo.Methods 60 male SD rats were randomly divided into 5 groups(n=12):P group,ischemia-reperfusion(IR group),S1 group,S2 group,S3 group.Myocardial IR injury was established.The pathological changes of cardiac muscle were observed under light microscope.Expression of Bax and Bcl-2 proteins and apoptosis index(AI) of myocardium cell were detected.Results Compared wit... |
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| Keywords: | Sevoflurane Postconditioning Myocardial ischemia reperfusion injury Apoptosis |
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